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Acknowledgement to Reviewers of Toxins in 2013
Toxins 2014, 6(3), 784-795; doi:10.3390/toxins6030784
Article

Nerve Growth Factor from Cobra Venom Inhibits the Growth of Ehrlich Tumor in Mice

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Received: 12 November 2013 / Revised: 14 February 2014 / Accepted: 17 February 2014 / Published: 26 February 2014
(This article belongs to the Section Animal Venoms)
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Abstract

The effects of nerve growth factor (NGF) from cobra venom (cvNGF) on growth of Ehrlich ascites carcinoma (EAC) cells inoculated subcutaneously in mice have been studied. The carcinoma growth slows down, but does not stop, during a course of cvNGF injections and restores after the course has been discontinued. The maximal anti-tumor effect has been observed at a dose of 8 nmoles cvNGF/kg body weight. cvNGF does not impact on lifespan of mice with grafted EAC cells. K252a, a tyrosine kinase inhibitor, attenuates the anti-tumor effect of cvNGF indicating the involvement of TrkA receptors in the process. cvNGF has induced also increase in body weight of the experimental animals. In overall, cvNGF shows the anti-tumor and weight-increasing effects which are opposite to those described for mammalian NGF (mNGF). However in experiments on breast cancer cell line MCF-7 cvNGF showed the same proliferative effects as mNGF and had no cytotoxic action on tumor cells in vitro. These data suggest that cvNGF slows down EAC growth via an indirect mechanism in which TrkA receptors are involved.
Keywords: Ehrlich carcinoma; K252a; nerve growth factor; TrkA receptor; MCF-7 cell line Ehrlich carcinoma; K252a; nerve growth factor; TrkA receptor; MCF-7 cell line
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Osipov, A.V.; Terpinskaya, T.I.; Kryukova, E.V.; Ulaschik, V.S.; Paulovets, L.V.; Petrova, E.A.; Blagun, E.V.; Starkov, V.G.; Utkin, Y.N. Nerve Growth Factor from Cobra Venom Inhibits the Growth of Ehrlich Tumor in Mice. Toxins 2014, 6, 784-795.

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