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Toxins 2014, 6(1), 194-210; doi:10.3390/toxins6010194
Review

Cytotoxic Proteins and Therapeutic Targets in Severe Cutaneous Adverse Reactions

1
 and 1,2,*
Received: 28 November 2013; in revised form: 20 December 2013 / Accepted: 27 December 2013 / Published: 3 January 2014
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Abstract: Severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN), are rare but life-threatening conditions induced mainly by a variety of drugs. Until now, an effective treatment for SJS/TEN still remains unavailable. Current studies have suggested that the pathobiology of drug-mediated SJS and TEN involves major histocompatibility class (MHC) I-restricted activation of cytotoxic T lymphocytes (CTLs) response. This CTLs response requires several cytotoxic signals or mediators, including granulysin, perforin/granzyme B, and Fas/Fas ligand, to trigger extensive keratinocyte death. In this article, we will discuss the cytotoxic mechanisms of severe cutaneous adverse reactions and their potential applications on therapeutics for this disease.
Keywords: Stevens-Johnson syndrome; toxic epidermal necrosis; granulysin; perforin; granzyme B; Fas/Fas ligand Stevens-Johnson syndrome; toxic epidermal necrosis; granulysin; perforin; granzyme B; Fas/Fas ligand
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Su, S.-C.; Chung, W.-H. Cytotoxic Proteins and Therapeutic Targets in Severe Cutaneous Adverse Reactions. Toxins 2014, 6, 194-210.

AMA Style

Su S-C, Chung W-H. Cytotoxic Proteins and Therapeutic Targets in Severe Cutaneous Adverse Reactions. Toxins. 2014; 6(1):194-210.

Chicago/Turabian Style

Su, Shih-Chi; Chung, Wen-Hung. 2014. "Cytotoxic Proteins and Therapeutic Targets in Severe Cutaneous Adverse Reactions." Toxins 6, no. 1: 194-210.


Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert