Next Article in Journal
Signaling Cascades of Pasteurella multocida Toxin in Immune Evasion
Previous Article in Journal
Update on Staphylococcal Superantigen-Induced Signaling Pathways and Therapeutic Interventions
Article Menu

Export Article

Open AccessCommunication
Toxins 2013, 5(9), 1655-1663; doi:10.3390/toxins5091655

Influence of Carbohydrates on Secondary Metabolism in Fusarium avenaceum

Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University, Sohngaardsholmsvej 49, Aalborg DK-9000, Denmark
Author to whom correspondence should be addressed.
Received: 3 September 2013 / Revised: 16 September 2013 / Accepted: 16 September 2013 / Published: 24 September 2013
View Full-Text   |   Download PDF [874 KB, uploaded 24 September 2013]   |  


Fusarium avenaceum is a widespread pathogen of important crops in the temperate climate zones that can produce many bioactive secondary metabolites, including moniliformin, fusarin C, antibiotic Y, 2-amino-14,16-dimethyloctadecan-3-ol (2-AOD-3-ol), chlamydosporol, aurofusarin and enniatins. Here, we examine the production of these secondary metabolites in response to cultivation on different carbon sources in order to gain insight into the regulation and production of secondary metabolites in F. avenaceum. Seven monosaccharides (arabinose, xylose, fructose, sorbose, galactose, mannose, glucose), five disaccharides (cellobiose, lactose, maltose, sucrose and trehalose) and three polysaccharides (dextrin, inulin and xylan) were used as substrates. Three F. avenaceum strains were used in the experiments. These were all able to grow and produce aurofusarin on the tested carbon sources. Moniliformin and enniatins were produced on all carbon types, except on lactose, which suggest a common conserved regulation mechanism. Differences in the strains was observed for production of fusarin C, 2-AOD-3-ol, chlamydosporol and antibiotic Y, which suggests that carbon source plays a role in the regulation of their biosynthesis.
Keywords: secondary metabolites; moniliformin; enniatin; carbon; regulation; activation; creA secondary metabolites; moniliformin; enniatin; carbon; regulation; activation; creA
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Sørensen, J.L.; Giese, H. Influence of Carbohydrates on Secondary Metabolism in Fusarium avenaceum. Toxins 2013, 5, 1655-1663.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top