Toxins 2013, 5(9), 1655-1663; doi:10.3390/toxins5091655
Communication

Influence of Carbohydrates on Secondary Metabolism in Fusarium avenaceum

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Received: 3 September 2013; in revised form: 16 September 2013 / Accepted: 16 September 2013 / Published: 24 September 2013
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Fusarium avenaceum is a widespread pathogen of important crops in the temperate climate zones that can produce many bioactive secondary metabolites, including moniliformin, fusarin C, antibiotic Y, 2-amino-14,16-dimethyloctadecan-3-ol (2-AOD-3-ol), chlamydosporol, aurofusarin and enniatins. Here, we examine the production of these secondary metabolites in response to cultivation on different carbon sources in order to gain insight into the regulation and production of secondary metabolites in F. avenaceum. Seven monosaccharides (arabinose, xylose, fructose, sorbose, galactose, mannose, glucose), five disaccharides (cellobiose, lactose, maltose, sucrose and trehalose) and three polysaccharides (dextrin, inulin and xylan) were used as substrates. Three F. avenaceum strains were used in the experiments. These were all able to grow and produce aurofusarin on the tested carbon sources. Moniliformin and enniatins were produced on all carbon types, except on lactose, which suggest a common conserved regulation mechanism. Differences in the strains was observed for production of fusarin C, 2-AOD-3-ol, chlamydosporol and antibiotic Y, which suggests that carbon source plays a role in the regulation of their biosynthesis.
Keywords: secondary metabolites; moniliformin; enniatin; carbon; regulation; activation; creA
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MDPI and ACS Style

Sørensen, J.L.; Giese, H. Influence of Carbohydrates on Secondary Metabolism in Fusarium avenaceum. Toxins 2013, 5, 1655-1663.

AMA Style

Sørensen JL, Giese H. Influence of Carbohydrates on Secondary Metabolism in Fusarium avenaceum. Toxins. 2013; 5(9):1655-1663.

Chicago/Turabian Style

Sørensen, Jens L.; Giese, Henriette. 2013. "Influence of Carbohydrates on Secondary Metabolism in Fusarium avenaceum." Toxins 5, no. 9: 1655-1663.


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