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Toxins 2013, 5(3), 537-555; doi:10.3390/toxins5030537
Article

Sequence Divergence of the Enniatin Synthase Gene in Relation to Production of Beauvericin and Enniatins in Fusarium Species

1,*  and 2
Received: 2 January 2013; in revised form: 25 February 2013 / Accepted: 5 March 2013 / Published: 13 March 2013
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Abstract: Beauvericin (BEA) and enniatins (ENNs) are cyclic peptide mycotoxins produced by a wide range of fungal species, including pathogenic Fusaria. Amounts of BEA and ENNs were quantified in individual rice cultures of 58 Fusarium strains belonging to 20 species, originating from different host plant species and different geographical localities. The species identification of all strains was done on the basis of the tef-1α gene sequence. The main aim of this study was to analyze the variability of the esyn1 gene encoding the enniatin synthase, the essential enzyme of this metabolic pathway, among the BEA- and ENNs-producing genotypes. The phylogenetic analysis based on the partial sequence of the esyn1 gene clearly discriminates species producing exclusively BEA from those synthesizing mainly enniatin analogues.
Keywords: beauvericin; cyclic peptides; DNA markers; enniatins; Fusarium spp.; phylogeny beauvericin; cyclic peptides; DNA markers; enniatins; Fusarium spp.; phylogeny
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Stępień, Ł.; Waśkiewicz, A. Sequence Divergence of the Enniatin Synthase Gene in Relation to Production of Beauvericin and Enniatins in Fusarium Species. Toxins 2013, 5, 537-555.

AMA Style

Stępień Ł, Waśkiewicz A. Sequence Divergence of the Enniatin Synthase Gene in Relation to Production of Beauvericin and Enniatins in Fusarium Species. Toxins. 2013; 5(3):537-555.

Chicago/Turabian Style

Stępień, Łukasz; Waśkiewicz, Agnieszka. 2013. "Sequence Divergence of the Enniatin Synthase Gene in Relation to Production of Beauvericin and Enniatins in Fusarium Species." Toxins 5, no. 3: 537-555.


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