Toxins 2012, 4(4), 281-295; doi:10.3390/toxins4040281
Article

Influence of Mycotoxins and a Mycotoxin Adsorbing Agent on the Oral Bioavailability of Commonly Used Antibiotics in Pigs

Joline Goossens 1,* email, Virginie Vandenbroucke 1 email, Frank Pasmans 2 email, Siegrid De Baere 1 email, Mathias Devreese 1 email, Ann Osselaere 1 email, Elin Verbrugghe 2 email, Freddy Haesebrouck 2 email, Sarah De Saeger 3 email, Mia Eeckhout 4 email, Kris Audenaert 5 email, Geert Haesaert 5 email, Patrick De Backer 1 email and Siska Croubels 1 email
1 Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium 2 Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium 3 Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000 Gent, Belgium 4 Department of Food Science and Technology, Faculty of Applied Bioscience Engineering, University College Ghent, Valentin Vaerwyckweg 1, 9000 Gent, Belgium 5 Department of Plant Production, Faculty of Applied Bioscience Engineering, University College Ghent, Valentin Vaerwyckweg 1, 9000 Gent, Belgium
* Author to whom correspondence should be addressed.
Received: 20 February 2012; in revised form: 15 March 2012 / Accepted: 18 April 2012 / Published: 24 April 2012
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Abstract: It is recognized that mycotoxins can cause a variety of adverse health effects in animals, including altered gastrointestinal barrier function. It is the aim of the present study to determine whether mycotoxin-contaminated diets can alter the oral bioavailability of the antibiotics doxycycline and paromomycin in pigs, and whether a mycotoxin adsorbing agent included into diets interacts with those antibiotics. Experiments were conducted with pigs utilizing diets that contained blank feed, mycotoxin-contaminated feed (T-2 toxin or deoxynivalenol), mycotoxin-contaminated feed supplemented with a glucomannan mycotoxin binder, or blank feed supplemented with mycotoxin binder. Diets with T-2 toxin and binder or deoxynivalenol and binder induced increased plasma concentrations of doxycycline administered as single bolus in pigs compared to diets containing blank feed. These results suggest that complex interactions may occur between mycotoxins, mycotoxin binders, and antibiotics which could alter antibiotic bioavailability. This could have consequences for animal toxicity, withdrawal time for oral antibiotics, or public health.
Keywords: mycotoxins; mycotoxin binder; antibiotics; pigs; interaction; safety testing

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MDPI and ACS Style

Goossens, J.; Vandenbroucke, V.; Pasmans, F.; De Baere, S.; Devreese, M.; Osselaere, A.; Verbrugghe, E.; Haesebrouck, F.; De Saeger, S.; Eeckhout, M.; Audenaert, K.; Haesaert, G.; De Backer, P.; Croubels, S. Influence of Mycotoxins and a Mycotoxin Adsorbing Agent on the Oral Bioavailability of Commonly Used Antibiotics in Pigs. Toxins 2012, 4, 281-295.

AMA Style

Goossens J, Vandenbroucke V, Pasmans F, De Baere S, Devreese M, Osselaere A, Verbrugghe E, Haesebrouck F, De Saeger S, Eeckhout M, Audenaert K, Haesaert G, De Backer P, Croubels S. Influence of Mycotoxins and a Mycotoxin Adsorbing Agent on the Oral Bioavailability of Commonly Used Antibiotics in Pigs. Toxins. 2012; 4(4):281-295.

Chicago/Turabian Style

Goossens, Joline; Vandenbroucke, Virginie; Pasmans, Frank; De Baere, Siegrid; Devreese, Mathias; Osselaere, Ann; Verbrugghe, Elin; Haesebrouck, Freddy; De Saeger, Sarah; Eeckhout, Mia; Audenaert, Kris; Haesaert, Geert; De Backer, Patrick; Croubels, Siska. 2012. "Influence of Mycotoxins and a Mycotoxin Adsorbing Agent on the Oral Bioavailability of Commonly Used Antibiotics in Pigs." Toxins 4, no. 4: 281-295.

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