Toxins 2012, 4(10), 768-777; doi:10.3390/toxins4100768
Article

Antibody to Heat Shock Protein 70 (HSP70) Inhibits Human T-Cell Lymphoptropic Virus Type I (HTLV-I) Production by Transformed Rabbit T-Cell Lines

1 Faculty of Science, University of Damascus, Damascus, Syrian 2 Université de Bretagne Occidentale & Université Paris Sud, Endotoxines, Bat: 409, IGM, UMR 86216, 91405 Orsay cedex, France
* Author to whom correspondence should be addressed.
Received: 11 June 2012; in revised form: 12 September 2012 / Accepted: 14 September 2012 / Published: 26 September 2012
(This article belongs to the Special Issue Toxicity and Therapeutic Interventions in the Immune System)
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Abstract: Adult T cell leukemia is a fatal malignant transformation caused by the human T-cell lymphoptropic virus type I (HTLV-I). HTLV-I is only associated with the development of this disease in a small percentage of infected individuals. Using two rabbit transformed T-cell lines; RH/K30 (asymptomatic) and RH/K34 (leukemogenic), we have investigated the expression of heat shock proteins (HSP) 90 and 70 and the role of anti-HSPs antibodies on virus production. HSPs surface expression was higher on RH/K34 than RH/K30 cells. Heat treatment of cells increased the expression of HSPs proteins and virus production; HSPs augmentation was stabilized after 12 h and virus production reached a maximum between 8 h–12 h then returned to normal level after 24 h of culture. Incubation of cells only with rabbit anti-HSP 70 antibodies prevented virus production specifically in the leukemogenic cell line. The results indicate a relationship between HSP 70 and virus production.
Keywords: HTLV-I; leukemogenesis; heat shock proteins; antibodies; animal model

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MDPI and ACS Style

Fallouh, H.; Mahana, W. Antibody to Heat Shock Protein 70 (HSP70) Inhibits Human T-Cell Lymphoptropic Virus Type I (HTLV-I) Production by Transformed Rabbit T-Cell Lines. Toxins 2012, 4, 768-777.

AMA Style

Fallouh H, Mahana W. Antibody to Heat Shock Protein 70 (HSP70) Inhibits Human T-Cell Lymphoptropic Virus Type I (HTLV-I) Production by Transformed Rabbit T-Cell Lines. Toxins. 2012; 4(10):768-777.

Chicago/Turabian Style

Fallouh, Hanan; Mahana, Wahib. 2012. "Antibody to Heat Shock Protein 70 (HSP70) Inhibits Human T-Cell Lymphoptropic Virus Type I (HTLV-I) Production by Transformed Rabbit T-Cell Lines." Toxins 4, no. 10: 768-777.

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