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Toxins 2010, 2(6), 1207-1224; doi:10.3390/toxins2061207

Overcoming Multidrug Resistance in Human Cancer Cells by Natural Compounds

Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Higashi-jima, Akiha-ku, Niigata 956-8603, Japan
Received: 30 April 2010 / Revised: 26 May 2010 / Accepted: 27 May 2010 / Published: 28 May 2010
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Abstract

Multidrug resistance is a phenomenon whereby tumors become resistant to structurally unrelated anticancer drugs. P-glycoprotein belongs to the large ATP-binding cassette (ABC) transporter superfamily of membrane transport proteins. P-glycoprotein mediates resistance to various classes of anticancer drugs including vinblastine, daunorubicin, and paclitaxel, by actively extruding the drugs from the cells. The quest for inhibitors of anticancer drug efflux transporters has uncovered natural compounds, including (-)-epigallocatechin gallate, curcumin, capsaicin, and guggulsterone, as promising candidates. In this review, studies on the effects of natural compounds on P-glycoprotein and anticancer drug efflux transporters are summarized.
Keywords: P-glycoprotein; ABC transporter; anticancer drug; multidrug resistance; phytochemical; cancer chemoprevention P-glycoprotein; ABC transporter; anticancer drug; multidrug resistance; phytochemical; cancer chemoprevention
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Nabekura, T. Overcoming Multidrug Resistance in Human Cancer Cells by Natural Compounds. Toxins 2010, 2, 1207-1224.

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