Toxins 2010, 2(12), 2851-2871; doi:10.3390/toxins2122851
Review

Spider-Venom Peptides as Therapeutics

email, email, email, email, email, email and * email
Received: 16 November 2010; in revised form: 17 December 2010 / Accepted: 17 December 2010 / Published: 20 December 2010
(This article belongs to the Special Issue Toxins as Therapeutics)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Spiders are the most successful venomous animals and the most abundant terrestrial predators. Their remarkable success is due in large part to their ingenious exploitation of silk and the evolution of pharmacologically complex venoms that ensure rapid subjugation of prey. Most spider venoms are dominated by disulfide-rich peptides that typically have high affinity and specificity for particular subtypes of ion channels and receptors. Spider venoms are conservatively predicted to contain more than 10 million bioactive peptides, making them a valuable resource for drug discovery. Here we review the structure and pharmacology of spider-venom peptides that are being used as leads for the development of therapeutics against a wide range of pathophysiological conditions including cardiovascular disorders, chronic pain, inflammation, and erectile dysfunction.
Keywords: spider venom; peptide; therapeutics; drugs; drug discovery; cystine knot
PDF Full-text Download PDF Full-Text [416 KB, uploaded 20 December 2010 12:40 CET]

Export to BibTeX |
EndNote


MDPI and ACS Style

Saez, N.J.; Senff, S.; Jensen, J.E.; Er, S.Y.; Herzig, V.; Rash, L.D.; King, G.F. Spider-Venom Peptides as Therapeutics. Toxins 2010, 2, 2851-2871.

AMA Style

Saez NJ, Senff S, Jensen JE, Er SY, Herzig V, Rash LD, King GF. Spider-Venom Peptides as Therapeutics. Toxins. 2010; 2(12):2851-2871.

Chicago/Turabian Style

Saez, Natalie J.; Senff, Sebastian; Jensen, Jonas E.; Er, Sing Yan; Herzig, Volker; Rash, Lachlan D.; King, Glenn F. 2010. "Spider-Venom Peptides as Therapeutics." Toxins 2, no. 12: 2851-2871.

Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert