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Toxins 2018, 10(4), 160; https://doi.org/10.3390/toxins10040160

Ribosome Inactivating Proteins: From Plant Defense to Treatments against Human Misuse or Diseases

Service d’Ingénierie Moléculaire des Protéines (SIMOPRO), CEA, Université Paris-Saclay, LabEx LERMIT, 91191 Gif-sur-Yvette, France
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Received: 11 April 2018 / Revised: 11 April 2018 / Accepted: 13 April 2018 / Published: 18 April 2018
(This article belongs to the Special Issue Ribosome Inactivating Toxins)
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Abstract

Ribosome inactivating proteins (RIPs) form a vast family of hundreds of toxins from plants, fungi, algae, and bacteria. RIP activities have also been detected in animal tissues. They exert an N-glycosydase catalytic activity that is targeted to a single adenine of a ribosomal RNA, thereby blocking protein synthesis and leading intoxicated cells to apoptosis. In many cases, they have additional depurinating activities that act against other nucleic acids, such as viral RNA and DNA, or genomic DNA. Although their role remains only partially understood, their functions may be related to plant defense against predators and viruses, plant senescence, or bacterial pathogenesis. View Full-Text
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Barbier, J.; Gillet, D. Ribosome Inactivating Proteins: From Plant Defense to Treatments against Human Misuse or Diseases. Toxins 2018, 10, 160.

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