Ginseng Extract G115 Attenuates Ethanol-Induced Depression in Mice by Increasing Brain BDNF Levels
Abstract
:1. Introduction
2. Materials and Methods
2.1. Drugs and Chemicals
2.2. Animals and Treatment
2.3. Behavioral Testing
2.3.1. Open Field Test
2.3.2. Forced Swimming Test
2.4. Western Immunoblotting
2.5. Statistical Analysis
3. Results
3.1. Forced Swimming Test
3.2. Locomotor Activity
3.3. BDNF Levels in the Hippocampus
3.4. BDNF Levels in the Prefrontal Cortex
4. Discussion
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Groups | Treatment | Groups | Treatment |
---|---|---|---|
Normal Mice | Ethanol-Treated Mice | ||
1. Control | Water p.o. + Water i.p. | 7. EtOH | Water p.o. + Ethanol i.p. |
2. AMI | Amitriptyline p.o. + Water i.p. | 8. EtOH + AMI | Amitriptyline p.o. + Ethanol i.p. |
3. G100 | G115 100 mg/kg p.o. + Water i.p. | 9. EtOH + G100 | G115 100 mg/kg p.o. + Ethanol i.p. |
4. G200 | G115 200 mg/kg p.o. + Water i.p. | 10. EtOH + G200 | G115 200 mg/kg p.o. + Ethanol i.p. |
5. G400 | G115 400 mg/kg p.o. + Water i.p. | 11. EtOH + G400 | G115 400 mg/kg p.o. + Ethanol i.p. |
6. G800 | G115 800 mg/kg p.o. + Water i.p. | 12. EtOH + G800 | G115 800 mg/kg p.o. + Ethanol i.p. |
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Boonlert, W.; Benya-aphikul, H.; Umka Welbat, J.; Rodsiri, R. Ginseng Extract G115 Attenuates Ethanol-Induced Depression in Mice by Increasing Brain BDNF Levels. Nutrients 2017, 9, 931. https://doi.org/10.3390/nu9090931
Boonlert W, Benya-aphikul H, Umka Welbat J, Rodsiri R. Ginseng Extract G115 Attenuates Ethanol-Induced Depression in Mice by Increasing Brain BDNF Levels. Nutrients. 2017; 9(9):931. https://doi.org/10.3390/nu9090931
Chicago/Turabian StyleBoonlert, Weerawan, Hattaya Benya-aphikul, Jariya Umka Welbat, and Ratchanee Rodsiri. 2017. "Ginseng Extract G115 Attenuates Ethanol-Induced Depression in Mice by Increasing Brain BDNF Levels" Nutrients 9, no. 9: 931. https://doi.org/10.3390/nu9090931