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Nutrients 2017, 9(9), 1039; doi:10.3390/nu9091039

Different Effects of Maternal Low-Isoflavone Soy Protein and Genistein Consumption on Hepatic Lipid Metabolism of 21-Day-Old Male Rat Offspring

1,†,‡
,
1,2,‡
and
1,2,*
1
Department of Food and Nutrition, Seoul National University, Seoul 08826, Korea
2
Research Institute of Human Ecology, Seoul National University, Seoul 08826, Korea
Current address: Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 3 August 2017 / Revised: 7 September 2017 / Accepted: 18 September 2017 / Published: 20 September 2017
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Abstract

Amino acid composition and isoflavone are alleged contributors to the beneficial effects of soy protein isolate (SPI) on lipid metabolism. Therefore, we investigated the contributing component(s) of SPI in a maternal diet to the regulation of lipid metabolism in offspring. We also determined serum parameters in dams to investigate specific maternal cues that might be responsible for this regulation. Female rats were fed either a casein (CAS), a low-isoflavone SPI, or a casein plus genistein (GEN, 250 mg/kg) diet for two weeks before mating, as well as during pregnancy and lactation. Male offspring (CAS, SPI and GEN groups) were studied 21 days after birth. The SPI group had lower serum triglyceride levels than the other groups. Serum cholesterol was reduced in both the SPI and GEN groups compared with the CAS group. Expressions of target genes of peroxisome proliferator-activated receptor α were altered in the SPI group. Serum aromatic amino acid levels in dams were associated with serum triglyceride in offspring. In conclusion, the maternal consumption of a low-isoflavone SPI diet or a casein diet containing genistein has different effects on the lipid metabolism of their offspring; however, more profound effects were observed in the SPI group. Therefore, the altered lipid metabolism of offspring may be attributed to amino acid composition in maternal dietary protein sources. View Full-Text
Keywords: amino acid; lipid metabolism; maternal diet; offspring liver; PPARα; soy protein isolate amino acid; lipid metabolism; maternal diet; offspring liver; PPARα; soy protein isolate
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Han, A.; Won, S.B.; Kwon, Y.H. Different Effects of Maternal Low-Isoflavone Soy Protein and Genistein Consumption on Hepatic Lipid Metabolism of 21-Day-Old Male Rat Offspring. Nutrients 2017, 9, 1039.

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