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Nutrients 2017, 9(9), 1004; doi:10.3390/nu9091004

Effect of Oral Pre-Meal Administration of Betaglucans on Glycaemic Control and Variability in Subjects with Type 1 Diabetes

Department of Endocrinology, Skåne University Hospital, 205 04 Malmö, Sweden
Metabolic Unit, CNR Institute of Neuroscience, 35127 Padova, Italy
Steno Diabetes Center, 2820 Gentofte, Denmark
Department of Clinical Sciences, Lund University, 205 04 Malmö, Sweden
Author to whom correspondence should be addressed.
Received: 25 July 2017 / Revised: 6 September 2017 / Accepted: 7 September 2017 / Published: 12 September 2017
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We conducted a double-blind placebo-controlled crossover pilot study to investigate the effect of oat betaglucans (β-glucan) on glycaemic control and variability in adults with type 1 diabetes (T1D; n = 14). Stomacol® tablets (1.53 g of β-glucan) or placebo (Plac) were administered three times daily before meals for two weeks. Glucose levels were monitored during the second week by continuous glucose monitoring (CGM). There was an increase in basic measures of glycaemic control (maximal glucose value 341 ± 15 vs. 378 ± 13 mg/dL for Plac and β-glucan, p = 0.004), and average daily risk range (62 ± 5 vs. 79 ± 4 mg/dL for Plac and β-glucan, p = 0.003) favouring Plac over β-glucan, but no increase in the M-value (the weighted average of the glucose values) or other more complex measures. Basic measures of glucose variability were also slightly increased during β-glucan treatment, with no difference in more complex measures. However, glycaemic variability increased between the first and last two CGM days on Plac, but remained unchanged on β-glucan. In conclusion, in this pilot study we were unable to demonstrate a general positive effect of β-glucan before meals on glucose control or variability in T1D. View Full-Text
Keywords: betaglucan; viscous fiber; diabetes; glucose control; glucose variability betaglucan; viscous fiber; diabetes; glucose control; glucose variability

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Frid, A.; Tura, A.; Pacini, G.; Ridderstråle, M. Effect of Oral Pre-Meal Administration of Betaglucans on Glycaemic Control and Variability in Subjects with Type 1 Diabetes. Nutrients 2017, 9, 1004.

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