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Nutrients 2017, 9(7), 790; doi:10.3390/nu9070790

Prenatal Vitamin D Intake, Cord Blood 25-Hydroxyvitamin D, and Offspring Body Composition: The Healthy Start Study

1
Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA
2
Department of Epidemiology, Colorado School of Public Health, Aurora, CO 80045, USA
3
Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO 80045, USA
*
Author to whom correspondence should be addressed.
Received: 13 June 2017 / Revised: 12 July 2017 / Accepted: 18 July 2017 / Published: 22 July 2017
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Abstract

Vitamin D deficiency in pregnancy may be associated with increased offspring adiposity, but evidence from human studies is inconclusive. We examined associations between prenatal vitamin D intake, 25-hydroxyvitamin D (25(OH)D) in cord blood, and offspring size and body composition at birth and 5 months. Participants included 605 mother-offspring dyads from the Healthy Start study, an ongoing, pre-birth prospective cohort study in Denver, Colorado, USA. Prenatal vitamin D intake was assessed with diet recalls and questionnaires, and offspring body composition was measured via air displacement plethysmography at birth and 5 months. General linear univariate models were used for analysis, adjusting for maternal age, race/ethnicity, pre-pregnancy body mass index (BMI), offspring sex, and gestational age at birth. Non-Hispanic white race, lower pre-pregnancy BMI, higher prenatal vitamin D intake, and summer births were associated with higher cord blood 25(OH)D. Higher 25(OH)D was associated with lower birthweight (β = –6.22, p = 0.02), but as maternal BMI increased, this association became increasingly positive in direction and magnitude (β = 1.05, p = 0.04). Higher 25(OH)D was also associated with lower neonatal adiposity (β = –0.02, p < 0.05) but not after adjustment for maternal BMI (β = –0.01, p = 0.25). Cord blood 25(OH)D was not associated with offspring size or body composition at 5 months. Our data confirm the hypothesis that vitamin D exposure in early life is associated with neonatal body size and composition. Future research is needed to understand the implications of these associations as infants grow. View Full-Text
Keywords: vitamin D; pregnancy; birth; body composition; adiposity vitamin D; pregnancy; birth; body composition; adiposity
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Sauder, K.A.; Koeppen, H.J.; Shapiro, A.L.; Kalata, K.E.; Stamatoiu, A.V.; Ringham, B.M.; Glueck, D.H.; Norris, J.M.; Dabelea, D. Prenatal Vitamin D Intake, Cord Blood 25-Hydroxyvitamin D, and Offspring Body Composition: The Healthy Start Study. Nutrients 2017, 9, 790.

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