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Nutrients 2017, 9(7), 758; doi:10.3390/nu9070758

Dietary Phytochemicals Promote Health by Enhancing Antioxidant Defence in a Pig Model

1
Faculty of Veterinary and Agricultural, The University of Melbourne, Parkville, VIC 3010, Australia
2
CSIRO Agriculture and Food, 671 Sneydes Road, Werribee, VIC 3010, Australia
*
Author to whom correspondence should be addressed.
Received: 8 June 2017 / Revised: 5 July 2017 / Accepted: 12 July 2017 / Published: 14 July 2017
(This article belongs to the Special Issue Effects of Polyphenol-Rich Foods on Human Health)
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Abstract

Phytochemical-rich diets are protective against chronic diseases and mediate their protective effect by regulation of oxidative stress (OS). However, it is proposed that under some circumstances, phytochemicals can promote production of reactive oxygen species (ROS) in vitro, which might drive OS-mediated signalling. Here, we investigated the effects of administering single doses of extracts of red cabbage and grape skin to pigs. Blood samples taken at baseline and 30 min intervals for 4 hours following intake were analyzed by measures of antioxidant status in plasma, including Trolox equivalent antioxidant capacity (TEAC) and glutathione peroxidase (GPx) activity. In addition, dose-dependent production of hydrogen peroxide (H2O2) by the same extracts was measured in untreated commercial pig plasma in vitro. Plasma from treated pigs showed extract dose-dependent increases in non-enzymatic (plasma TEAC) and enzymatic (GPx) antioxidant capacities. Similarly, extract dose-dependent increases in H2O2 were observed in commercial pig plasma in vitro. The antioxidant responses to extracts by treated pigs were highly correlated with their respective yields of H2O2 production in vitro. These results support that dietary phytochemicals regulate OS via direct and indirect antioxidant mechanisms. The latter may be attributed to the ability to produce H2O2 and to thereby stimulate cellular antioxidant defence systems. View Full-Text
Keywords: hydrogen peroxide; reactive oxygen species; plant extracts; red cabbage; grape; glutathione peroxide; total antioxidant capacity; porcine; piglet; Landrace hydrogen peroxide; reactive oxygen species; plant extracts; red cabbage; grape; glutathione peroxide; total antioxidant capacity; porcine; piglet; Landrace
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MDPI and ACS Style

Selby-Pham, S.N.B.; Cottrell, J.J.; Dunshea, F.R.; Ng, K.; Bennett, L.E.; Howell, K.S. Dietary Phytochemicals Promote Health by Enhancing Antioxidant Defence in a Pig Model. Nutrients 2017, 9, 758.

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