Next Article in Journal
Spirulina Protects against Hepatic Inflammation in Aging: An Effect Related to the Modulation of the Gut Microbiota?
Next Article in Special Issue
Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High-Sucrose Diet
Previous Article in Journal
An Increased Dietary Supply of Medium-Chain Fatty Acids during Early Weaning in Rodents Prevents Excessive Fat Accumulation in Adulthood
Previous Article in Special Issue
Carbohydrates from Sources with a Higher Glycemic Index during Adolescence: Is Evening Rather than Morning Intake Relevant for Risk Markers of Type 2 Diabetes in Young Adulthood?
Article Menu
Issue 6 (June) cover image

Export Article

Open AccessArticle
Nutrients 2017, 9(6), 632; doi:10.3390/nu9060632

PREVIEW: Prevention of Diabetes through Lifestyle Intervention and Population Studies in Europe and around the World. Design, Methods, and Baseline Participant Description of an Adult Cohort Enrolled into a Three-Year Randomised Clinical Trial

1
Department of Food and Environmental Sciences, University of Helsinki, 00014 Helsinki, Finland
2
Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Rolighedsvej 30, Frederiksberg C, DK-1958 Copenhagen, Denmark
3
Department of Human Biology, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
4
School of Life Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham NG7 2UH, UK
5
Center for Nutrition Research, University of Navarra, 31008 Pamplona, Spain
6
CIBERobn, Instituto de Salud Carlos III, 28029 Madrid, Spain
7
Department of pharmacology and toxicology, Medical University of Sofia, 1431 Sofia, Bulgaria
8
Human Nutrition Unit, School of Biological Sciences, University of Auckland, Auckland 1024, New Zealand
9
Department of Exercise and Health Sciences, University of Stuttgart, 70569 Stuttgart, Germany
10
School of Sport and Exercise Sciences, A.STEM Research Centre, Swansea University, Swansea SA1 8EN, UK
11
National Institute for Health and Welfare THL, 00300 Helsinki, Finland
12
NetUnion sarl, Ave des Figuires 20, 1007 Lausanne, Switzerland
13
Charles Perkins Centre, University of Sydney, Sydney 2006, Australia
14
Department of Health Science, University of Education Schwäbisch Gmünd, 73525 Gmünd, Germany
*
Author to whom correspondence should be addressed.
Received: 14 May 2017 / Revised: 4 June 2017 / Accepted: 16 June 2017 / Published: 20 June 2017
(This article belongs to the Special Issue Nutrition and Diet Factors in Type 2 Diabetes)
View Full-Text   |   Download PDF [927 KB, uploaded 22 June 2017]   |  

Abstract

Type-2 diabetes (T2D) is one of the fastest growing chronic diseases worldwide. The PREVIEW project has been initiated to find the most effective lifestyle (diet and physical activity) for the prevention of T2D, in overweight and obese participants with increased risk for T2D. The study is a three-year multi-centre, 2 × 2 factorial, randomised controlled trial. The impact of a high-protein, low-glycaemic index (GI) vs. moderate protein, moderate-GI diet in combination with moderate or high-intensity physical activity on the incidence of T2D and the related clinical end-points are investigated. The intervention started with a two-month weight reduction using a low-calorie diet, followed by a randomised 34-month weight maintenance phase comprising four treatment arms. Eight intervention centres are participating (Denmark, Finland, United Kingdom, The Netherlands, Spain, Bulgaria, Australia, and New Zealand). Data from blood specimens, urine, faeces, questionnaires, diaries, body composition assessments, and accelerometers are collected at months 0, 2, 6, 12, 18, 24, and 36. In total, 2326 adults were recruited. The mean age was 51.6 (SD 11.6) years, 67% were women. PREVIEW is, to date, the largest multinational trial to address the prevention of T2D in pre-diabetic adults through diet and exercise intervention. Participants will complete the final intervention in March, 2018. View Full-Text
Keywords: diet; protein; carbohydrate; glycaemic index; physical activity; obesity diet; protein; carbohydrate; glycaemic index; physical activity; obesity
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Fogelholm, M.; Larsen, T.M.; Westerterp-Plantenga, M.; Macdonald, I.; Martinez, J.A.; Boyadjieva, N.; Poppitt, S.; Schlicht, W.; Stratton, G.; Sundvall, J.; Lam, T.; Jalo, E.; Christensen, P.; Drummen, M.; Simpson, E.; Navas-Carretero, S.; Handjieva-Darlenska, T.; Muirhead, R.; Silvestre, M.P.; Kahlert, D.; Pastor-Sanz, L.; Brand-Miller, J.; Raben, A. PREVIEW: Prevention of Diabetes through Lifestyle Intervention and Population Studies in Europe and around the World. Design, Methods, and Baseline Participant Description of an Adult Cohort Enrolled into a Three-Year Randomised Clinical Trial. Nutrients 2017, 9, 632.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top