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Nutrients 2017, 9(6), 595; doi:10.3390/nu9060595

Comparison of Prognostic Impact between the Child-Pugh Score and Skeletal Muscle Mass for Patients with Liver Cirrhosis

Department of Hepatobiliary and Pancreatic disease, Department of Internal Medicine, Hyogo College of Medicine, 1-1, Mukogawacho, Nishinomiyashi, Hyogo 663-8501, Japan
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Received: 13 May 2017 / Revised: 8 June 2017 / Accepted: 9 June 2017 / Published: 12 June 2017
(This article belongs to the Special Issue Nutrition and Liver Disease)
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Abstract

Aims: To investigate the influence of skeletal muscle mass index (SMI) as determined by bioimpedance analysis (BIA) (appendicular skeletal muscle mass/(height)2) on survival by comparing the Child-Pugh score in patients with liver cirrhosis (LC, n = 383, average age = 65.2 years). Patients and methods: In terms of comparison of the effects of SMI and other markers on survival, we used time-dependent receiver operating characteristics (ROC) analysis. Results: The average SMI for male was 7.4 cm2/m2 whereas that for female was 6.0 cm2/m2 (p < 0.0001). As for the Child-Pugh score, five points were in the majority, both in males (51.7%, (106/205)) and females (44.9%, (80/178)). For both genders, the survival curve was well stratified according to SMI (p < 0.0001 for males and p = 0.0056 for females). In the multivariate analysis for survival, SMI and Child-Pugh scores were found to be significant both in males and females. In time-dependent ROC analyses, all area under the ROCs (AUROCs) for SMI in each time point were higher than those for Child-Pugh scores in males, while in females AUROCs for Child-Pugh scores at each time point were higher than those for SMI. Conclusion: SMI using BIA can be helpful for predicting outcomes, at least in male LC patients. View Full-Text
Keywords: liver cirrhosis; bioimpedance analysis; skeletal muscle mass index; Child-Pugh score; prognosis liver cirrhosis; bioimpedance analysis; skeletal muscle mass index; Child-Pugh score; prognosis
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Nishikawa, H.; Enomoto, H.; Ishii, A.; Iwata, Y.; Miyamoto, Y.; Ishii, N.; Yuri, Y.; Hasegawa, K.; Nakano, C.; Nishimura, T.; Yoh, K.; Aizawa, N.; Sakai, Y.; Ikeda, N.; Takashima, T.; Takata, R.; Iijima, H.; Nishiguchi, S. Comparison of Prognostic Impact between the Child-Pugh Score and Skeletal Muscle Mass for Patients with Liver Cirrhosis. Nutrients 2017, 9, 595.

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