The Evolving Interplay among Abundant Adipokines in Patients with Hepatitis C during Viral Clearance
AbstractHow hepatatitis C virus (HCV) infection affects the interplay among abundant adipokines in the host remains unclear. A prospective study was conducted with 450 consecutive genotype 1 (G1) and G2 HCV patients who completed a course of anti-HCV therapy and underwent pre-therapy and 24-week post-therapy surveys to assess various profiles and levels of abundant adipokines, including leptin, adiponectin, and plasminogen activator inhibitor-1 (PAI-1). Before anti-HCV therapy, multivariate analyses showed gender to be associated with leptin and adiponectin levels, and BMI with leptin and PAI-1 levels. Among patients with a sustained virological response (SVR, n = 372), associations at 24 weeks post-therapy were as follows: gender and BMI with all adipokine levels; hepatic steatosis and aspartate aminotransferase to platelet ratio index with adiponectin levels; and HOMA-IR and HCV genotype with PAI-1 levels. Paired t-tests revealed increased post-therapeutic PAI-1 levels in G1 SVR patients and decreased adiponectin levels in all SVR patients compared to pre-therapeutic levels. HCV infection may obscure associations between abundant adipokines and metabolic/hepatic profiles. In SVR patients, a higher hierarchical status of PAI-1 versus adiponectin in affecting glucose metabolism was noted at 24 weeks post-therapy. Such genotype-non-specific adiponectin decreases and G1-specific PAI-1 increases warrant careful follow-up of HCV patients after SVR according to viral genotype. View Full-Text
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Chang, M.-L.; Chen, T.-H.; Hsu, C.-M.; Lin, C.-H.; Lin, C.-Y.; Kuo, C.-J.; Huang, S.-W.; Chen, C.-W.; Cheng, H.-T.; Yeh, C.-T.; Chiu, C.-T. The Evolving Interplay among Abundant Adipokines in Patients with Hepatitis C during Viral Clearance. Nutrients 2017, 9, 570.
Chang M-L, Chen T-H, Hsu C-M, Lin C-H, Lin C-Y, Kuo C-J, Huang S-W, Chen C-W, Cheng H-T, Yeh C-T, Chiu C-T. The Evolving Interplay among Abundant Adipokines in Patients with Hepatitis C during Viral Clearance. Nutrients. 2017; 9(6):570.Chicago/Turabian Style
Chang, Ming-Ling; Chen, Tsung-Hsing; Hsu, Chen-Ming; Lin, Cheng-Hui; Lin, Cheng-Yu; Kuo, Chia-Jung; Huang, Shu-Wei; Chen, Chun-Wei; Cheng, Hao-Tsai; Yeh, Chau-Ting; Chiu, Cheng-Tang. 2017. "The Evolving Interplay among Abundant Adipokines in Patients with Hepatitis C during Viral Clearance." Nutrients 9, no. 6: 570.