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Nutrients 2017, 9(6), 561; doi:10.3390/nu9060561

Chronic Inflammatory Diseases and Green Tea Polyphenols

Department of Physiology, Internal Medicine, College of Medicine, University of Kentucky Medical Center, Lexington, KY 40536-0298, USA
Received: 22 April 2017 / Revised: 27 May 2017 / Accepted: 29 May 2017 / Published: 1 June 2017
(This article belongs to the Special Issue Nutrients, Infectious and Inflammatory Diseases)
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Abstract

Chronic inflammatory diseases affect millions of people globally and the incidence rate is on the rise. While inflammation contributes to the tissue healing process, chronic inflammation can lead to life-long debilitation and loss of tissue function and organ failure. Chronic inflammatory diseases include hepatic, gastrointestinal and neurodegenerative complications which can lead to malignancy. Despite the millennial advancements in diagnostic and therapeutic modalities, there remains no effective cure for patients who suffer from inflammatory diseases. Therefore, patients seek alternatives and complementary agents as adjunct therapies to relieve symptoms and possibly to prevent consequences of inflammation. It is well known that green tea polyphenols (GrTPs) are potent antioxidants with important roles in regulating vital signaling pathways. These comprise transcription nuclear factor-kappa B mediated I kappa B kinase complex pathways, programmed cell death pathways like caspases and B-cell lymphoma-2 and intervention with the surge of inflammatory markers like cytokines and production ofcyclooxygenase-2. This paper concisely reviews relevant investigations regarding protective effects of GrTPs and some reported adverse effects, as well as possible applications for GrTPs in the treatment of chronic and inflammatory complications. View Full-Text
Keywords: chronic inflammatory diseases; green tea polyphenols; (−)-Epigallocatechin-3-gallate (EGCG) chronic inflammatory diseases; green tea polyphenols; (−)-Epigallocatechin-3-gallate (EGCG)
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Oz, H.S. Chronic Inflammatory Diseases and Green Tea Polyphenols. Nutrients 2017, 9, 561.

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