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Nutrients 2017, 9(6), 553; doi:10.3390/nu9060553

Body Composition Analysis Allows the Prediction of Urinary Creatinine Excretion and of Renal Function in Chronic Kidney Disease Patients

Department of Clinical and Experimental Medicine, Division of Nephrology, University of Pisa, I-56100 Pisa, Italy
Received: 20 February 2017 / Revised: 9 May 2017 / Accepted: 23 May 2017 / Published: 28 May 2017
(This article belongs to the Special Issue Nutrition and Chronic Kidney Disease)
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Abstract

The aim of this study was to predict urinary creatinine excretion (UCr), creatinine clearance (CCr) and the glomerular filtration rate (GFR) from body composition analysis. Body cell mass (BCM) is the compartment which contains muscle mass, which is where creatinine is generated. BCM was measured with body impedance analysis in 165 chronic kidney disease (CKD) adult patients (72 women) with serum creatinine (SCr) 0.6–14.4 mg/dL. The GFR was measured (99mTc-DTPA) and was predicted using the Modification of Diet in Renal Disease (MDRD) formula. The other examined parameters were SCr, 24-h UCr and measured 24-h CCr (mCCr). A strict linear correlation was found between 24-h UCr and BCM (r = 0.772). Multiple linear regression (MR) indicated that UCr was positively correlated with BCM, body weight and male gender, and negatively correlated with age and SCr. UCr predicted using the MR equation (MR-UCr) was quite similar to 24-h UCr. CCr predicted from MR-UCr and SCr (MR-BCM-CCr) was very similar to mCCr with a high correlation (r = 0.950), concordance and a low prediction error (8.9 mL/min/1.73 m2). From the relationship between the GFR and the BCM/SCr ratio, we predicted the GFR (BCM GFR). The BCM GFR was very similar to the GFR with a high correlation (r = 0.906), concordance and a low prediction error (12.4 mL/min/1.73 m2). In CKD patients, UCr, CCr and the GFR can be predicted from body composition analysis. View Full-Text
Keywords: glomerular filtration rate; 24-h urinary creatinine excretion; creatinine clearance; estimate of renal function; body composition analysis; body cell mass; electrical body impedance glomerular filtration rate; 24-h urinary creatinine excretion; creatinine clearance; estimate of renal function; body composition analysis; body cell mass; electrical body impedance
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Donadio, C. Body Composition Analysis Allows the Prediction of Urinary Creatinine Excretion and of Renal Function in Chronic Kidney Disease Patients. Nutrients 2017, 9, 553.

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