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Nutrients 2017, 9(5), 488; doi:10.3390/nu9050488

B-Vitamin Intake from Diet and Supplements and Breast Cancer Risk in Middle-Aged Women: Results from the Prospective NutriNet-Santé Cohort

Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), Inserm U1153, Inra U1125, Cnam, Paris 13 University, Nutritional Epidemiology Research Team (EREN), 74 rue Marcel Cachin, 93017 Bobigny, France
French Network for Nutrition and Cancer Research (NACRe Network), 78352 Jouy-en-Josas, France
Oncology Department, Avicenne Hospital, 93017 Bobigny, France
UFR Pharmacie, Inra, UMR 1019, CRNH Auvergne, Centre Jean-Perrin, CHU Gabriel-Montpied, Unité de Nutrition, Clermont Université, Université d’Auvergne, 63000 Clermont-Ferrand, France
Public Health Department, Avicenne Hospital, 93017 Bobigny, France
Author to whom correspondence should be addressed.
Received: 2 March 2017 / Revised: 9 May 2017 / Accepted: 10 May 2017 / Published: 13 May 2017
View Full-Text   |   Download PDF [303 KB, uploaded 13 May 2017]


Experimental studies suggest a protective effect of B-vitamins on breast cancer risk, potentially modulated by alcohol intake. However, epidemiological studies are limited, especially regarding non-folate B-vitamins. Furthermore, few studies included quantitative assessment of supplemental intake. This prospective study aimed to investigate the associations between intakes of B-vitamins (dietary, supplemental, total) and breast cancer risk. 27,853 women aged ≥45 years from the NutriNet-Santé cohort (2009–2016) were included, with a median follow-up time of 4.2 years. Dietary data were collected using repeated 24 h records. A specific questionnaire assessed dietary supplement use over a 12-month period. A composition database of 8000 supplements was developed. Associations were characterized by multivariable Cox models, and 462 incident breast cancers were diagnosed. Dietary (HRQ4vs.Q1 = 0.74 (0.55, 0.99), P-trend = 0.05), supplemental (HRQ4vs.Q1 = 0.61 (0.38, 0.98), P-trend = 0.05), and total (HRQ4vs.Q1 = 0.67 (0.50, 0.91), P-trend = 0.01) pyridoxine intakes were inversely associated with breast cancer risk. Total thiamin intake was borderline inversely associated with breast cancer risk (HRper 1-unit increment = 0.78 (0.61, 1.00), P = 0.05). Statistically significant interactions between alcohol consumption and B-vitamin (thiamin, riboflavin, niacin, pantothenic acid, pyridoxine, folate, and cobalamin) supplemental intake were observed, the latter being inversely associated with breast cancer risk in non-to-low alcohol drinkers but not in higher drinkers. This large prospective study, including quantitative assessment of supplemental intake, suggests a potential protective effect of pyridoxine and thiamin on breast cancer risk in middle-aged women. View Full-Text
Keywords: B-vitamins; diet; dietary supplements; prospective cohort; breast cancer risk B-vitamins; diet; dietary supplements; prospective cohort; breast cancer risk
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Egnell, M.; Fassier, P.; Lécuyer, L.; Zelek, L.; Vasson, M.-P.; Hercberg, S.; Latino-Martel, P.; Galan, P.; Deschasaux, M.; Touvier, M. B-Vitamin Intake from Diet and Supplements and Breast Cancer Risk in Middle-Aged Women: Results from the Prospective NutriNet-Santé Cohort. Nutrients 2017, 9, 488.

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