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Nutrients 2017, 9(4), 340; doi:10.3390/nu9040340

Plasma Vitamin D Deficiency Is Associated With Poor Sleep Quality and Night-Time Eating at Mid-Pregnancy in Singapore

1
Department of Paediatrics, KK Women’s and Children’s Hospital, 100, Bukit Timah Road, Singapore 229899, Singapore
2
School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 7 Sassoon Road, Pokfulam, Hong Kong, China
3
Department of Reproductive Medicine, KK Women’s and Children’s Hospital, 100, Bukit Timah Road, Singapore 229899, Singapore
4
Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore
5
Center for Quantitative Medicine, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore
6
Tampere Center for Child Health Research, University of Tampere and Tampere University Hospital, Kalevantie 4, Tampere 33100, Finland
7
Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Rd 119228, NUHS Tower Block, Level 11, Singapore 117597, Singapore
8
Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, (A*STAR), 30 Medical Drive, Singapore 117609, Singapore
9
MRC Lifecourse Epidemiology Unit, University of Southampton, University Road, Southampton SO17 1BJ, UK
10
NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, University Road, Southampton SO17 1BJ, UK
11
Maternal Fetal Medicine, KK Women’s and Children’s Hospital, 100, Bukit Timah Road, Singapore 229899, Singapore
12
Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Rd 119228, NUHS Tower Block, Level 11, Singapore 117597, Singapore
13
Khoo Teck Puat-National University Children’s Medical Institute, National University Hospital, National University Health System, 5 Lower Kent Ridge Road, Singapore 119074, Singapore
14
Saw Swee Hock School of Public Health, National University of Singapore, 1E Kent Ridge Rd 119228, NUHS Tower Block, Level 11, Singapore 117597, Singapore
15
Clinical Nutrition Research Centre, Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), 14 Medical Drive #07-02, MD 6 Building, Singapore 117599, Singapore
16
Lee Kong Chian School of Medicine, Nanyang Technological University, 50 Nanyang Ave, Singapore 639798, Singapore
*
Author to whom correspondence should be addressed.
Received: 15 February 2017 / Revised: 19 March 2017 / Accepted: 27 March 2017 / Published: 29 March 2017
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Abstract

Plasma 25-hydroxyvitamin D (25OHD) deficiency, poor sleep quality, and night-time eating, have been independently associated with adverse pregnancy outcomes, but their inter-relationships are yet to be evaluated. We aimed to investigate the associations between maternal plasma 25OHD status and sleep quality and circadian eating patterns during pregnancy. Data on pregnant women (n = 890) from a prospective cohort (Growing Up in Singapore Towards healthy Outcomes) were analyzed. Plasma 25OHD concentration was measured, while the Pittsburgh sleep quality index (PSQI) and 24-h dietary recall were administered to women at 26–28 weeks’ gestation. Plasma 25OHD status was defined as sufficient (>75 nmol/L), insufficient (50–75 nmol/L), or deficient (<50 nmol/L). Poor sleep quality was defined by a total global PSQI score >5. Predominantly day-time (pDT) and predominantly night-time (pNT) were defined according to consumption of greater proportion of calories (i.e., >50%) from 07:00–18:59 and from 19:00–06:59, respectively. After adjustment for confounders, women with plasma 25OHD deficiency had higher odds of poor sleep quality (odds ratio (OR) 3.49; 95% confidence interval (CI) 1.84–6.63) and pNT eating (OR: 1.85; 95% CI 1.00–3.41) than those who were 25OHD sufficient. Our findings show the association of maternal plasma 25OHD deficiency with poor sleep quality and pNT eating at mid-pregnancy. View Full-Text
Keywords: vitamin D; behavioral circadian rhythms; sleep quality; predominantly night-time eating vitamin D; behavioral circadian rhythms; sleep quality; predominantly night-time eating
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Cheng, T.S.; Loy, S.L.; Cheung, Y.B.; Cai, S.; Colega, M.T.; Godfrey, K.M.; Chong, Y.-S.; Tan, K.H.; Shek, L.P.-C.; Lee, Y.S.; Lek, N.; Chan, J.K.Y.; Chong, M.F.-F.; Yap, F. Plasma Vitamin D Deficiency Is Associated With Poor Sleep Quality and Night-Time Eating at Mid-Pregnancy in Singapore. Nutrients 2017, 9, 340.

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