Next Article in Journal
The Prevalence of Micronutrient Deficiencies and  Inadequacies in the Middle East and Approaches to  Interventions
Previous Article in Journal
Antioxidants for Healthy Skin: The Emerging Role of Aryl Hydrocarbon Receptors and Nuclear Factor-Erythroid 2-Related Factor-2
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessArticle
Nutrients 2017, 9(3), 228; doi:10.3390/nu9030228

Partially Hydrolyzed Guar Gum Increases  Ferroportin Expression in the Colon of Anemic  Growing Rats

1
School of Health Sciences, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul 79825‐070, Brazil
2
School of Exact Sciences and Technology, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul 79825‐070, Brazil
3
Center of Biological Sciences and Health, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul 79825‐070, Brazil
*
Author to whom correspondence should be addressed.
Received: 22 November 2016 / Accepted: 28 February 2017 / Published: 3 March 2017
View Full-Text   |   Download PDF [584 KB, uploaded 6 March 2017]   |  

Abstract

Studies have reported a positive effect of prebiotics on the bioavailability of iron. This study evaluated the effect of partially hydrolyzed guar gum (PHGG) on iron absorption mechanisms in anemic rats. Male Wistar rats were fed 75g American Institute of Nutrition Rodent Diets for growth, pregnancy and lactation (AIN93‐G) without iron for three weeks in order to induce iron deficiency anemia. Then they were fed a control diet (n = 12; without fiber) or a diet with 7.5% of PHGG (n = 12), both without iron. Food intake, body growth and the feed efficiency coefficient (FEC) were measured. The animals were euthanized after two weeks of treatment. The weight of the organs, the pH of the cecal content, and the hepatic iron and ferroportin expression in the cecum, duodenum, and liver were assessed. The intake of PHGG reduced food intake without affecting body growth, and there was a difference between the groups regarding the FEC (p = 0.026), with the highest value found in the PHGG group. The weight of the cecal content increased (p ≤ 0.001) and the pH of the cecal content was significantly lower in the PHGG group. The intake of PHGG significantly increased ferroportin expression in the cecum; however, the difference was not significant in the duodenum and the liver. PHGG seems to have a positive influence on iron absorption through transporter expression, and structural and physiological changes in the colon of anemic growing animals. View Full-Text
Keywords: dietary fiber; animal model; rats; anemia; iron; growth dietary fiber; animal model; rats; anemia; iron; growth
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Carvalho, L.; Brait, D.; Vaz, M.; Lollo, P.; Morato, P.; Oesterreich, S.; Raposo, J.; Freitas, K. Partially Hydrolyzed Guar Gum Increases  Ferroportin Expression in the Colon of Anemic  Growing Rats. Nutrients 2017, 9, 228.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top