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Nutrients 2017, 9(3), 182; doi:10.3390/nu9030182

The Relationship between Maternal Plasma Leptin and Adiponectin Concentrations and Newborn Adiposity

1
Nutrition Department, School of Public Health, University of São Paulo, São Paulo 01246-904, Brazil
2
Postgraduate Program in Applied Human Nutrition (PRONUT), University of São Paulo, São Paulo 05508-000, Brazil
3
Immunology Center, Adolfo Lutz Institute, São Paulo 05403-000, Brazil
4
Institute for Global Health, University College London, London WC1N 1EH, UK
*
Author to whom correspondence should be addressed.
Received: 11 May 2016 / Revised: 20 October 2016 / Accepted: 25 October 2016 / Published: 23 February 2017
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Abstract

Increased maternal blood concentrations of leptin and decreased adiponectin levels, which are common disturbances in obesity, may be involved in offspring adiposity by programming fetal adipose tissue development. The aim of this study was to assess the relationship between maternal leptin and adiponectin concentrations and newborn adiposity. This was a cross-sectional study involving 210 healthy mother-newborn pairs from a public maternity hospital in São Paulo, Brazil. Maternal blood samples were collected after delivery and leptin and adiponectin concentrations were measured by enzyme-linked immunosorbent assay. Newborn body composition was estimated by air displacement plethysmography. The association between maternal leptin and adiponectin concentrations and newborn adiposity (fat mass percentage, FM%) was evaluated by multiple linear regression, controlling for maternal age, socioeconomic status, parity, pre-pregnancy body mass index (BMI), weight gain, gestational age, and newborn age at the time of measurement. No relationship was found between maternal leptin and FM% of male or female newborn infants. Maternal adiponectin (p = 0.001) and pre-pregnancy BMI (p < 0.001; adj. R2 = 0.19) were positively associated with FM% of newborn males, indicating that maternal adiponectin is involved in fetal fat deposition in a sex-specific manner. Large-scale epidemiological, longitudinal studies are necessary to confirm our results. View Full-Text
Keywords: leptin; adiponectin; adiposity; mother; newborn leptin; adiponectin; adiposity; mother; newborn
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Castro, N.P.; Euclydes, V.V.; Simões, F.A.; Vaz-de-Lima, L.R.A.; De Brito, C.A.; Luzia, L.A.; Devakumar, D.; Rondó, P.H.C. The Relationship between Maternal Plasma Leptin and Adiponectin Concentrations and Newborn Adiposity. Nutrients 2017, 9, 182.

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