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Nutrients 2017, 9(12), 1377; https://doi.org/10.3390/nu9121377

Peripheral Endocannabinoid Responses to Hedonic Eating in Binge-Eating Disorder

1
Department of Psychiatry, University of Campania Luigi Vanvitelli, 80138 Naples, Italy
2
Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, 80078 Pozzuoli, Naples, Italy
3
Department of Eating and Weight Disorders, Villa Garda Hospital, 37016 Garda, Verona, Italy
4
Neuroscience Section, Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Salerno, Italy
*
Authors to whom correspondence should be addressed.
Received: 19 November 2017 / Revised: 13 December 2017 / Accepted: 19 December 2017 / Published: 20 December 2017
(This article belongs to the Special Issue Binge Eating Disorder)
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Abstract

Reward mechanisms are likely implicated in the pathophysiology of binge-eating behaviour, which is a key symptom of binge-eating disorder (BED). Since endocannabinoids modulate food-related reward, we aimed to investigate the responses of anandamide (AEA) and 2-arachidonoylglycerol (2-AG) to hedonic eating in patients with BED. Peripheral levels of AEA and 2-AG were measured in 7 obese BED patients before and after eating favorite (hedonic eating) and non-favorite (non-hedonic eating) foods. We found that plasma levels of AEA progressively decreased after eating the non-favorite food and significantly increased after eating the favorite food, whereas plasma levels of 2-AG did not differ significantly between the two test conditions, although they showed a trend toward significantly different time patterns. The changes in peripheral AEA levels were positively correlated to the subjects’ sensations of the urge to eat and the pleasantness while eating the presented food, while changes in peripheral 2-AG levels were positively correlated to the subjects’ sensation of the pleasantness while eating the presented food and to the amount of food they would eat. These results suggest the occurrence of distinctive responses of endocannabinoids to food-related reward in BED. The relevance of such findings to the pathophysiology of BED remains to be elucidated. View Full-Text
Keywords: anandamide; binge-eating disorder; 2-arachidonoylglycerol; endocannabinoids; hedonic eating anandamide; binge-eating disorder; 2-arachidonoylglycerol; endocannabinoids; hedonic eating
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Monteleone, A.M.; Piscitelli, F.; Dalle Grave, R.; El Ghoch, M.; Di Marzo, V.; Maj, M.; Monteleone, P. Peripheral Endocannabinoid Responses to Hedonic Eating in Binge-Eating Disorder. Nutrients 2017, 9, 1377.

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