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Nutrients 2017, 9(12), 1374; doi:10.3390/nu9121374

Effect of an Extract from Aronia melanocarpa L. Berries on the Body Status of Zinc and Copper under Chronic Exposure to Cadmium: An In Vivo Experimental Study

Department of Toxicology, Medical University of Bialystok, Adama Mickiewicza 2C Street, 15-222 Bialystok, Poland
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Received: 10 September 2017 / Revised: 14 November 2017 / Accepted: 12 December 2017 / Published: 19 December 2017
(This article belongs to the Special Issue Effects of Polyphenol-Rich Foods on Human Health)
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Abstract

In an experimental model of low-level and moderate environmental human exposure to cadmium (Cd), it was investigated whether the consumption of a polyphenol-rich Aronia melanocarpa L. berries (chokeberries) extract (AE) may influence the body status of zinc (Zn) and copper (Cu). The bioelements’ apparent absorption, body retention, serum and tissue concentrations, total pool in internal organs, excretion, and the degree of binding to metallothionein were evaluated in female rats administered 0.1% aqueous AE or/and Cd in their diet (1 and 5 mg/kg) for 3–24 months. The consumption of AE alone had no influence on the body status of Zn and Cu. The extract administration at both levels of Cd treatment significantly (completely or partially) protected against most of the changes in the metabolism of Zn and Cu caused by this xenobiotic; however, it increased or decreased some of the Cd-unchanged indices of their body status. Based on the findings, it seems that rational amounts of chokeberry products may be included in the daily diet without the risk of destroying Zn and Cu metabolisms; however, their potential prophylactic use under exposure to Cd needs further study to exclude any unfavourable impact of these essential elements on the metabolism. View Full-Text
Keywords: apparent absorption; Aronia melanocarpa berries; body status; cadmium; copper; excretion; metabolism; metallothionein; polyphenols; tissue concentrations; zinc apparent absorption; Aronia melanocarpa berries; body status; cadmium; copper; excretion; metabolism; metallothionein; polyphenols; tissue concentrations; zinc
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Borowska, S.; Brzóska, M.M.; Gałażyn-Sidorczuk, M.; Rogalska, J. Effect of an Extract from Aronia melanocarpa L. Berries on the Body Status of Zinc and Copper under Chronic Exposure to Cadmium: An In Vivo Experimental Study. Nutrients 2017, 9, 1374.

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