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Nutrients 2017, 9(12), 1320; doi:10.3390/nu9121320

The Effects of Phytosterols Extracted from Diascorea alata on the Antioxidant Activity, Plasma Lipids, and Hematological Profiles in Taiwanese Menopausal Women

1
Graduate Institute of Medical Science, Chang Jung Christian University, Tainan 71101, Taiwan
2
Department of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei 110, Taiwan
3
Department of Health Management, I-Shou University, Kaohsiung 84001, Taiwan
4
Department of Obstetrics and Gynecology, Chang Gung University School of Medicine and Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan
5
San an Obstetrics and Gynecology Hospital, 177 Meisu East 2nd Road, Kaohsiung 804, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 13 September 2017 / Revised: 29 November 2017 / Accepted: 29 November 2017 / Published: 5 December 2017
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Abstract

The efficacy of phytosterols extracted from Diascorea alata on antioxidant activities, plasma lipids and hematological profiles was assessed in postmenopausal women. Gas chromatography and mass spectrophotometry was employed to determine the steroid content of Taiwanese yam (Diascorea alata cv. Tainung No. 2). A two-center, randomized, double-blind, placebo-controlled clinical investigation on 50 postmenopausal women randomly assigned to two groups treated for 12 months with placebo or two sachets daily of Diascorea extracts containing 12 mg/dose was carried out. The main outcome measures were the plasma antioxidant activities, hematological profiles, and the concentrations of plasma lipids, including cholesterol, triglyceride, low density lipoprotein, high density lipoprotein, very low density lipoprotein,, and apolipoprotein A1 and B. A one-way analysis of covariance (ANCOVA) test was performed to investigate the significance. Beta-sitosterol, stigmasterol, 22-23-dihydro-, and γ-sitosterol were major phytosterols determined from Diascorea extracts. At six months in those receiving Diascorea, there were significantly decreased leukocyte counts (p < 0.01) and improvement on antioxidant activity of malondialdehyde (p < 0.001). After 12 months’ treatment, elevations of hematocrit and mean corpuscular volume (p < 0.01) were noted in those receiving Diascorea. Moreover, the low dose Diascorea consumption in menopausal women for one year generally did not present positive effects on lipid profiles. View Full-Text
Keywords: Diascorea; phytosterol; menopause; hematological profiles; lipid profile; antioxidant activity; breast cyst Diascorea; phytosterol; menopause; hematological profiles; lipid profile; antioxidant activity; breast cyst
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Hsu, C.-C.; Kuo, H.-C.; Huang, K.-E. The Effects of Phytosterols Extracted from Diascorea alata on the Antioxidant Activity, Plasma Lipids, and Hematological Profiles in Taiwanese Menopausal Women. Nutrients 2017, 9, 1320.

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