Next Article in Journal
Prevalence of Pre-Diabetes across Ethnicities: A Review of Impaired Fasting Glucose (IFG) and Impaired Glucose Tolerance (IGT) for Classification of Dysglycaemia
Next Article in Special Issue
Zinc as a Gatekeeper of Immune Function
Previous Article in Journal
A Cross-Sectional Study on the Association between 24-h Urine Osmolality and Weight Status in Older Adults
Previous Article in Special Issue
Fatty Acids, Antioxidants and Physical Activity in Brain Aging
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessArticle
Nutrients 2017, 9(11), 1270; doi:10.3390/nu9111270

Acute Effects of Nitrate-Rich Beetroot Juice on Blood Pressure, Hemostasis and Vascular Inflammation Markers in Healthy Older Adults: A Randomized, Placebo-Controlled Crossover Study

1
Tissue Repair and Translational Physiology Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, OLD 4059, Australia
2
School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, OLD 4059, Australia
3
School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane, OLD 4059, Australia
4
Institute of Sport Exercise and Active Living, Victoria University, Melbourne, VIC 8001, Australia
5
School of Exercise and Nutrition Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, OLD 4059, Australia
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 23 October 2017 / Revised: 9 November 2017 / Accepted: 12 November 2017 / Published: 22 November 2017
(This article belongs to the Special Issue Immunology: Nutrition, Exercise and Adiposity Relationships)
View Full-Text   |   Download PDF [2294 KB, uploaded 22 November 2017]   |  

Abstract

Aging is associated with a vasoconstrictive, pro-coagulant, and pro-inflammatory profile of arteries and a decline in the bioavailability of the endothelium-derived molecule nitric oxide. Dietary nitrate elicits vasodilatory, anti-coagulant and anti-inflammatory effects in younger individuals, but little is known about whether these benefits are evident in older adults. We investigated the effects of 140 mL of nitrate-rich (HI-NI; containing 12.9 mmol nitrate) versus nitrate-depleted beetroot juice (LO-NI; containing ≤0.04 mmol nitrate) on blood pressure, blood coagulation, vascular inflammation markers, plasma nitrate and nitrite before, and 3 h and 6 h after ingestion in healthy older adults (five males, seven females, mean age: 64 years, age range: 57–71 years) in a randomized, placebo-controlled, crossover study. Plasma nitrate and nitrite increased 3 and 6 h after HI-NI ingestion (p < 0.05). Systolic, diastolic and mean arterial blood pressure decreased 3 h relative to baseline after HI-NI ingestion only (p < 0.05). The number of blood monocyte-platelet aggregates decreased 3 h after HI-NI intake (p < 0.05), indicating reduced platelet activation. The number of blood CD11b-expressing granulocytes decreased 3 h following HI-NI beetroot juice intake (p < 0.05), suggesting a shift toward an anti-adhesive granulocyte phenotype. Numbers of blood CD14++CD16+ intermediate monocyte subtypes slightly increased 6 h after HI-NI beetroot juice ingestion (p < 0.05), but the clinical implications of this response are currently unclear. These findings provide new evidence for the acute effects of nitrate-rich beetroot juice on circulating immune cells and platelets. Further long-term research is warranted to determine if these effects reduce the risk of developing hypertension and vascular inflammation with aging. View Full-Text
Keywords: beetroot juice; dietary nitrate; anti-thrombotic effects; anti-adhesive effects; low-grade inflammation; thrombosis; blood pressure; aging; preserving vascular health beetroot juice; dietary nitrate; anti-thrombotic effects; anti-adhesive effects; low-grade inflammation; thrombosis; blood pressure; aging; preserving vascular health
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Raubenheimer, K.; Hickey, D.; Leveritt, M.; Fassett, R.; Ortiz de Zevallos Munoz, J.; Allen, J.D.; Briskey, D.; Parker, T.J.; Kerr, G.; Peake, J.M.; Pecheniuk, N.M.; Neubauer, O. Acute Effects of Nitrate-Rich Beetroot Juice on Blood Pressure, Hemostasis and Vascular Inflammation Markers in Healthy Older Adults: A Randomized, Placebo-Controlled Crossover Study. Nutrients 2017, 9, 1270.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top