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Nutrients 2017, 9(11), 1196; doi:10.3390/nu9111196

Caffeine at a Moderate Dose Did Not Affect the Skeletal System of Rats with Streptozotocin-Induced Diabetes

1
Department of Pharmacology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, 40-055 Katowice, Poland
2
Department of Clinical and Experimental Pharmacotherapy, Medical Faculty, Slovak Medical University, 833 03 Bratislava, Slovakia
*
Author to whom correspondence should be addressed.
Received: 21 July 2017 / Revised: 24 October 2017 / Accepted: 25 October 2017 / Published: 30 October 2017
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Abstract

Diabetes may lead to the development of osteoporosis. Coffee drinking, apart from its health benefits, is taken into consideration as an osteoporosis risk factor. Data from human and animal studies on coffee and caffeine bone effects are inconsistent. The aim of the study was to investigate effects of caffeine at a moderate dose on the skeletal system of rats in two models of experimental diabetes induced by streptozotocin. Effects of caffeine administered orally (20 mg/kg aily for four weeks) were investigated in three-month-old female Wistar rats, which, two weeks before the start of caffeine administration, received streptozotocin (60 mg/kg, intraperitoneally) alone or streptozotocin after nicotinamide (230 mg/kg, intraperitoneally). Bone turnover markers, mass, mineral density, histomorphometric parameters, and mechanical properties were examined. Streptozotocin induced diabetes, with profound changes in the skeletal system due to increased bone resorption and decreased bone formation. Although streptozotocin administered after nicotinamide induced slight increases in glucose levels at the beginning of the experiment only, slight, but significant unfavorable changes in the skeletal system were demonstrated. Administration of caffeine did not affect the investigated skeletal parameters of rats with streptozotocin-induced disorders. In conclusion, caffeine at a moderate dose did not exert a damaging effect on the skeletal system of diabetic rats. View Full-Text
Keywords: caffeine; streptozotocin; diabetes; skeletal system; rats caffeine; streptozotocin; diabetes; skeletal system; rats
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Folwarczna, J.; Janas, A.; Cegieła, U.; Pytlik, M.; Śliwiński, L.; Matejczyk, M.; Nowacka, A.; Rudy, K.; Krivošíková, Z.; Štefíková, K.; Gajdoš, M. Caffeine at a Moderate Dose Did Not Affect the Skeletal System of Rats with Streptozotocin-Induced Diabetes. Nutrients 2017, 9, 1196.

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