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Nutrients 2017, 9(10), 1122; doi:10.3390/nu9101122

Resveratrol and Amyloid-Beta: Mechanistic Insights

1
Department of Neuropharmacology, Research Institute of Medicine and Pharmacy, Qiqihar Medical University, Qiqihar 161006, China
2
Department of Pathophysiology, Qiqihar Medical University, Qiqihar 161006, China
*
Author to whom correspondence should be addressed.
Received: 19 August 2017 / Revised: 25 September 2017 / Accepted: 2 October 2017 / Published: 14 October 2017
(This article belongs to the Special Issue Effects of Resveratrol Supplementation on Human Health and Disease)
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Abstract

The amyloid-beta (Aβ) hypothesis that dyshomeostasis between Aβ production and clearance is a very early, key molecular factor in the etiology of Alzheimer’s disease (AD) has been proposed and examined in the AD research field. Scientists have focused on seeking natural products or drugs to influence the dynamic equilibrium of Aβ, targeting production and clearance of Aβ. There is emerging evidence that resveratrol (Res), a naturally occurring polyphenol mainly found in grapes and red wine, acts on AD in numerous in vivo and in vitro models. Res decreases the amyloidogenic cleavage of the amyloid precursor protein (APP), enhances clearance of amyloid beta-peptides, and reduces Aβ aggregation. Moreover, Res also protects neuronal functions through its antioxidant properties. This review discusses the action of Res on Aβ production, clearance and aggregation and multiple potential mechanisms, providing evidence of the useful of Res for AD treatment. View Full-Text
Keywords: resveratrol; amyloid-beta; alzheimer disease; transporter; blood-brain-barrier resveratrol; amyloid-beta; alzheimer disease; transporter; blood-brain-barrier
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Jia, Y.; Wang, N.; Liu, X. Resveratrol and Amyloid-Beta: Mechanistic Insights. Nutrients 2017, 9, 1122.

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