Next Article in Journal
Serum 25-Hydroxyvitamin D Concentrations and Indicators of Mental Health: An Analysis of the Canadian Health Measures Survey
Previous Article in Journal
Flavanol-Rich Cocoa Powder Interacts with Lactobacillus rhamnossus LGG to Alter the Antibody Response to Infection with the Parasitic Nematode Ascaris suum
Previous Article in Special Issue
Cyanidin Stimulates Insulin Secretion and Pancreatic β-Cell Gene Expression through Activation of l-type Voltage-Dependent Ca2+ Channels
Article Menu
Issue 10 (October) cover image

Export Article

Open AccessReview
Nutrients 2017, 9(10), 1111; doi:10.3390/nu9101111

Dietary Anthocyanins and Insulin Resistance: When Food Becomes a Medicine

1
G.B. Pant Institute of Himalayan Environment and Development, Kosi Katarmal, Almora, Uttarakhand 263643, India
2
Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran P.O. Box 19395-5487, Iran
3
Pharmacognosy Research Laboratories & Herbal Analysis Services UK, University of Greenwich, Central Avenue, Charham-Maritime, Kent ME4 4TB, UK
*
Author to whom correspondence should be addressed.
Received: 4 September 2017 / Revised: 24 September 2017 / Accepted: 10 October 2017 / Published: 12 October 2017
(This article belongs to the Special Issue Nutrients, Bioactives and Insulin Resistance)
View Full-Text   |   Download PDF [893 KB, uploaded 16 October 2017]   |  

Abstract

Insulin resistance is an abnormal physiological state that occurs when insulin from pancreatic β-cells is unable to trigger a signal transduction pathway in target organs such as the liver, muscles and adipose tissues. The loss of insulin sensitivity is generally associated with persistent hyperglycemia (diabetes), hyperinsulinemia, fatty acids and/or lipid dysregulation which are often prevalent under obesity conditions. Hence, insulin sensitizers are one class of drugs currently employed to treat diabetes and associated metabolic disorders. A number of natural products that act through multiple mechanisms have also been identified to enhance insulin sensitivity in target organs. One group of such compounds that gained interest in recent years are the dietary anthocyanins. Data from their in vitro, in vivo and clinical studies are scrutinized in this communication to show their potential health benefit through ameliorating insulin resistance. Specific mechanism of action ranging from targeting specific signal transduction receptors/enzymes to the general antioxidant and anti-inflammatory mechanisms of insulin resistance are presented. View Full-Text
Keywords: dietary anthocyanins; insulin resistance; diabetes; obesity dietary anthocyanins; insulin resistance; diabetes; obesity
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Belwal, T.; Nabavi, S.F.; Nabavi, S.M.; Habtemariam, S. Dietary Anthocyanins and Insulin Resistance: When Food Becomes a Medicine. Nutrients 2017, 9, 1111.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top