Next Article in Journal
Beverage Consumption Patterns among Norwegian Adults
Next Article in Special Issue
Seasonal Epidemiology of Serum 25-Hydroxyvitamin D Concentrations among Healthy Adults Living in Rural and Urban Areas in Mongolia
Previous Article in Journal
The Anticancer Properties of Herba Epimedii and Its Main Bioactive Componentsicariin and Icariside II
Previous Article in Special Issue
Seasonal Changes in Vitamin D-Effective UVB Availability in Europe and Associations with Population Serum 25-Hydroxyvitamin D
Article Menu

Export Article

Open AccessArticle
Nutrients 2016, 8(9), 565;

Relationship between Vitamin D Status and Autonomic Nervous System Activity

Southern Adelaide Diabetes and Endocrine Services, Repatriation General Hospital, Adelaide, SA 5041, Australia
School of Medicine, Flinders University, Adelaide, SA 5042, Australia
Department of Clinical Pharmacology, Flinders Medical Centre, Adelaide, SA 5042, Australia
Author to whom correspondence should be addressed.
Received: 20 July 2016 / Revised: 31 August 2016 / Accepted: 6 September 2016 / Published: 13 September 2016
(This article belongs to the Special Issue Vitamin D: Current Issues and New Perspectives)
View Full-Text   |   Download PDF [474 KB, uploaded 13 September 2016]   |  


Vitamin D deficiency is associated with increased arterial stiffness. However, the mechanisms underlying this association have not been clarified. The aim was to investigate whether changes in autonomic nervous system activity could underlie an association between 25 hydroxy vitamin D and arterial stiffness. A total of 49 subjects (age = 60 ± 8 years, body mass index = 26.7 ± 4.6 kg/m2, 25 hydroxy vitamin D = 69 ± 22 nmol/L) underwent measurements of pulse wave velocity (PWV) and augmentation index (AIx), spontaneous baroreflex sensitivity, plasma metanephrines and 25 hydroxy vitamin D. Subjects with 25 hydroxy vitamin D ≤ 50 nmol/L were restudied after 200,000 International Units 25 hydroxy vitamin D. Plasma metanephrine was positively associated with AIx (p = 0.02) independent of age, sex, smoking and cholesterol and negatively associated with 25 hydroxy vitamin D (p = 0.002) independent of age, sex and season. In contrast, there was no association between baroreflex sensitivity and 25 hydroxy vitamin D (p = 0.54). Treatment with vitamin D increased 25 hydroxy vitamin D from 43 ± 5 to 96 ± 24 nmol/L (p < 0.0001) but there was no significant change in plasma metanephrine (115 ± 25 vs. 99 ± 39 pmol/L, p = 0.12). We conclude that as plasma metanephrine was negatively associated with 25 hydroxy vitamin D and positively with AIx, it could mediate an association between these two variables. This hypothesis should be tested in larger interventional studies. View Full-Text
Keywords: 25 hydroxy vitamin D; pulse wave velocity; augmentation index; baroreflex sensitivity; metanephrine 25 hydroxy vitamin D; pulse wave velocity; augmentation index; baroreflex sensitivity; metanephrine

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Burt, M.G.; Mangelsdorf, B.L.; Stranks, S.N.; Mangoni, A.A. Relationship between Vitamin D Status and Autonomic Nervous System Activity. Nutrients 2016, 8, 565.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top