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Nutrients 2016, 8(7), 424; doi:10.3390/nu8070424

Association between Toenail Mercury and Metabolic Syndrome Is Modified by Selenium

Department of Food and Nutrition, Yeungnam University, Gyeongsan 38541, Gyeongbuk, Korea
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Received: 13 June 2016 / Revised: 30 June 2016 / Accepted: 6 July 2016 / Published: 12 July 2016
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Abstract

Background: Although Asian populations consume relatively large amounts of fish and seafood and have a high prevalence of metabolic diseases, few studies have investigated the association between chronic mercury exposure and metabolic syndrome and its effect modification by selenium. Methods: We analyzed baseline data from the Trace Element Study of Korean Adults in the Yeungnam area. Participants included 232 men and 269 women, aged 35 years or older, who had complete data regarding demographic, lifestyle, diet, toenail mercury and selenium levels, and health. Toenail mercury and selenium concentrations were measured using instrumental neutron-activation analysis. The metabolic biomarker levels were obtained through biannual medical checkups. Results: Higher toenail mercury levels were associated with habitual consumption of whale and shark meats, older age, obesity, smoking, alcohol drinking, and higher household income. Multivariable analysis showed a positive association between toenail mercury exposure and metabolic syndrome. In addition, this association was significantly stronger at lower selenium levels and was weaker at higher selenium levels. Conclusion: The possible harmful effects of mercury on metabolic syndrome may be attenuated by high levels of selenium. Future studies are needed to suggest optimal dietary guidelines regarding fish and selenium intakes, particularly for Asians with high levels of fish intake. View Full-Text
Keywords: toenail mercury; metabolic syndrome; effect-modification; selenium; Asian toenail mercury; metabolic syndrome; effect-modification; selenium; Asian
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Park, K.; Seo, E. Association between Toenail Mercury and Metabolic Syndrome Is Modified by Selenium. Nutrients 2016, 8, 424.

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