Next Article in Journal
Impact of Food Components on in vitro Calcitonin Gene-Related Peptide Secretion—A Potential Mechanism for Dietary Influence on Migraine
Previous Article in Journal
Dairy Intake Enhances Body Weight and Composition Changes during Energy Restriction in 18–50-Year-Old Adults—A Meta-Analysis of Randomized Controlled Trials
Previous Article in Special Issue
Protein Consumption and the Elderly: What Is the Optimal Level of Intake?
Article Menu

Export Article

Open AccessFeature PaperReview
Nutrients 2016, 8(7), 404; doi:10.3390/nu8070404

Protecting Skeletal Muscle with Protein and Amino Acid during Periods of Disuse

1
Center for Rehabilitation and Physical Activity and Nutrition (CeRPAN), University of Texas Medical Branch, Galveston, TX 77555, USA
2
Department of Nutrition and Metabolism, University of Texas Medical Branch, Galveston, TX 77555, USA
3
Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong 3125, Australia
*
Author to whom correspondence should be addressed.
Received: 25 May 2016 / Revised: 16 June 2016 / Accepted: 23 June 2016 / Published: 1 July 2016
(This article belongs to the Special Issue Dietary Protein, Exercise and Muscle Health in an Ageing Population)
View Full-Text   |   Download PDF [418 KB, uploaded 1 July 2016]   |  

Abstract

Habitual sedentary behavior increases risk of chronic disease, hospitalization and poor quality of life. Short-term bed rest or disuse accelerates the loss of muscle mass, function, and glucose tolerance. Optimizing nutritional practices and protein intake may reduce the consequences of disuse by preserving metabolic homeostasis and muscle mass and function. Most modes of physical inactivity have the potential to negatively impact the health of older adults more than their younger counterparts. Mechanistically, mammalian target of rapamycin complex 1 (mTORC1) signaling and muscle protein synthesis are negatively affected by disuse. This contributes to reduced muscle quality and is accompanied by impaired glucose regulation. Simply encouraging increased protein and/or energy consumption is a well-intentioned, but often impractical strategy to protect muscle health. Emerging evidence suggests that leucine supplemented meals may partially and temporarily protect skeletal muscle during disuse by preserving anabolism and mitigating reductions in mass, function and metabolic homeostasis. View Full-Text
Keywords: leucine; bed rest; muscle health; inactivity; muscle protein synthesis; diet leucine; bed rest; muscle health; inactivity; muscle protein synthesis; diet
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Galvan, E.; Arentson-Lantz, E.; Lamon, S.; Paddon-Jones, D. Protecting Skeletal Muscle with Protein and Amino Acid during Periods of Disuse. Nutrients 2016, 8, 404.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top