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Nutrients 2016, 8(7), 396; doi:10.3390/nu8070396

Mangiferin and Cancer: Mechanisms of Action

1
Auckland Cancer Society Research Center, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
2
Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
*
Author to whom correspondence should be addressed.
Received: 20 April 2016 / Revised: 30 May 2016 / Accepted: 22 June 2016 / Published: 28 June 2016
(This article belongs to the Special Issue Polyphenols for Cancer Treatment or Prevention)
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Abstract

Mangiferin, a bioactive compound derived primarily from Anacardiaceae and Gentianaceae families and found in mangoes and honeybush tea, has been extensively studied for its therapeutic properties. Mangiferin has shown promising chemotherapeutic and chemopreventative potential. This review focuses on the effect of mangiferin on: (1) inflammation, with respect to NFκB, PPARү and the immune system; (2) cell cycle, the MAPK pathway G2/M checkpoint; (3) proliferation and metastasis, and implications on β-catenin, MMPs, EMT, angiogenesis and tumour volume; (4) apoptosis, with a focus on Bax/Bcl ratios, intrinsic/extrinsic apoptotic pathways and telomerase activity; (5) oxidative stress, through Nrf2/ARE signalling, ROS elimination and catalase activity; and (6) efficacy of chemotherapeutic agents, such as oxaliplatin, etoposide and doxorubicin. In addition, the need to enhance the bioavailability and delivery of mangiferin are briefly addressed, as well as the potential for toxicity. View Full-Text
Keywords: mangiferin; cancer; inflammation; NFκB; oxidative stress; cell cycle; combination therapy; nutraceuticals; bioavailability; hallmarks of cancer mangiferin; cancer; inflammation; NFκB; oxidative stress; cell cycle; combination therapy; nutraceuticals; bioavailability; hallmarks of cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Gold-Smith, F.; Fernandez, A.; Bishop, K. Mangiferin and Cancer: Mechanisms of Action. Nutrients 2016, 8, 396.

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