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Nutrients 2016, 8(6), 324; doi:10.3390/nu8060324

Association between Metabolite Profiles, Metabolic Syndrome and Obesity Status

1
Institute of Nutrition and Functional Foods (INAF), Laval University, Quebec City, QC G1V0A6, Canada
2
School of Nutrition, Laval University, Quebec City, QC G1V0A6, Canada
3
Laboratory of Molecular Pharmacology, CHU-Quebec Research Center, and Faculty of Pharmacy, Laval University, Quebec City, QC G1V4G2, Canada
4
Department of Kinesiology, Laval University, Quebec City, QC G1V0A6, Canada
*
Author to whom correspondence should be addressed.
Received: 13 April 2016 / Revised: 11 May 2016 / Accepted: 20 May 2016 / Published: 27 May 2016
(This article belongs to the Special Issue Metabolically Healthy Obesity)
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Abstract

Underlying mechanisms associated with the development of abnormal metabolic phenotypes among obese individuals are not yet clear. Our aim is to investigate differences in plasma metabolomics profiles between normal weight (NW) and overweight/obese (Ov/Ob) individuals, with or without metabolic syndrome (MetS). Mass spectrometry-based metabolite profiling was used to compare metabolite levels between each group. Three main principal components factors explaining a maximum of variance were retained. Factor 1’s (long chain glycerophospholipids) metabolite profile score was higher among Ov/Ob with MetS than among Ov/Ob and NW participants without MetS. This factor was positively correlated to plasma total cholesterol (total-C) and triglyceride levels in the three groups, to high density lipoprotein -cholesterol (HDL-C) among participants without MetS. Factor 2 (amino acids and short to long chain acylcarnitine) was positively correlated to HDL-C and negatively correlated with insulin levels among NW participants. Factor 3’s (medium chain acylcarnitines) metabolite profile scores were higher among NW participants than among Ov/Ob with or without MetS. Factor 3 was negatively associated with glucose levels among the Ov/Ob with MetS. Factor 1 seems to be associated with a deteriorated metabolic profile that corresponds to obesity, whereas Factors 2 and 3 seem to be rather associated with a healthy metabolic profile. View Full-Text
Keywords: metabolic syndrome; obesity; metabolites metabolic syndrome; obesity; metabolites
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Allam-Ndoul, B.; Guénard, F.; Garneau, V.; Cormier, H.; Barbier, O.; Pérusse, L.; Vohl, M.-C. Association between Metabolite Profiles, Metabolic Syndrome and Obesity Status. Nutrients 2016, 8, 324.

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