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Nutrients 2016, 8(4), 237; doi:10.3390/nu8040237

N-3 Polyunsaturated Fatty Acids Improve Liver Lipid Oxidation-Related Enzyme Levels and Increased the Peroxisome Proliferator-Activated Receptor α Expression Level in Mice Subjected to Hemorrhagic Shock/Resuscitation

1
Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Zhongshan East Road 305, Nanjing 210002, China
2
Department of General Surgery, Jinling Hospital, Clinical College of Southern Medical University, Zhongshan East Road 305, Nanjing 210002, China
*
Author to whom correspondence should be addressed.
Received: 16 February 2016 / Revised: 9 April 2016 / Accepted: 15 April 2016 / Published: 22 April 2016
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Abstract

Appropriate metabolic interventions after hemorrhagic shock/resuscitation injury have not yet been identified. We aimed to examine the effects of fish oil on lipid metabolic intervention after hemorrhagic shock/resuscitation. Firstly, 48 C57BL/6 mice were assigned to six groups (n = 8 per group). The sham group did not undergo surgery, while mice in the remaining groups were sacrificed 1–5 days after hemorrhagic shock/resuscitation. In the second part, mice were treated with saline or fish oil (n = 8 per group) five days after injury. We determined serum triglyceride levels and liver tissues were collected and prepared for qRT-PCR or Western blot analysis. We found that triglyceride levels were increased five days after hemorrhagic shock/resuscitation, but decreased after addition of fish oil. After injury, the protein and gene expression of carnitine palmitoyltransferase 1A, fatty acid transport protein 1, and peroxisome proliferator-activated receptor-α decreased significantly in liver tissue. In contrast, after treatment with fish oil, the expression levels of these targets increased compared with those in the saline group. The present results suggest n-3 polyunsaturated fatty acids could improve lipid oxidation-related enzymes in liver subjected to hemorrhagic shock/resuscitation. This function is possibly accomplished through activating the peroxisome proliferator-activated receptor-α pathway. View Full-Text
Keywords: hemorrhagic shock; peroxisome proliferator-activated receptor; fatty acid oxidation; fish oil hemorrhagic shock; peroxisome proliferator-activated receptor; fatty acid oxidation; fish oil
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhang, L.; Tian, F.; Gao, X.; Wang, X.; Wu, C.; Li, N.; Li, J. N-3 Polyunsaturated Fatty Acids Improve Liver Lipid Oxidation-Related Enzyme Levels and Increased the Peroxisome Proliferator-Activated Receptor α Expression Level in Mice Subjected to Hemorrhagic Shock/Resuscitation. Nutrients 2016, 8, 237.

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