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Nutrients 2016, 8(3), 163; doi:10.3390/nu8030163

Micronutrients in Oncological Intervention

1
Akademie für Mikronährstoffmedizin, Essen, Zweigertstrasse 55, 45130 Essen, Germany
2
Interdisziplinäres onkologisches Zentrum (IOZ), München, Nußbaumstrasse 12, München 80336, Germany
3
Klinik Bad Trissl, Innere Medizin II-Onkologie und Komplementärmedizin, Oberaudorf 83080, Germany
4
St. Anna Hospital, Medizinische Klinik I, Herne, Hospitalstrasse 19, Herne 44649, Germany
5
Boston University Medical Center, 85 East Newton Street M-1033, Boston, MA 02118, USA
6
Klinik für Strahlentherapie und Radio-Onkologie, Ruhr Universität Bochum (RUB), Hölkeskampring 40, Herne 44625, Germany
*
Author to whom correspondence should be addressed.
Received: 23 November 2015 / Revised: 16 February 2016 / Accepted: 24 February 2016 / Published: 12 March 2016
View Full-Text   |   Download PDF [1144 KB, uploaded 12 March 2016]   |  

Abstract

Nutritional supplements are widely used among patients with cancer who perceive them to be anticancer and antitoxicity agents. Depending on the type of malignancy and the gender 30%–90% of the cancer patients supplement their diets with antioxidant and immuno-stabilizing micronutrients, such as selenium, vitamin C, and vitamin D, often without the knowledge of the treating physician. From the oncological viewpoint, there are justifiable concerns that dietary supplements decrease the effectiveness of chemotherapy and radiotherapy. Recent studies, however, have provided increasing evidence that treatment is tolerated better—with an increase in patient compliance and a lower rate of treatment discontinuations—when micronutrients, such as selenium, are added as appropriate to the patient’s medication. Nutritional supplementation tailored to an individual’s background diet, genetics, tumor histology, and treatments may yield benefits in subsets of patients. Clinicians should have an open dialogue with patients about nutritional supplements. Supplement advice needs to be individualized and come from a credible source, and it is best communicated by the physician. View Full-Text
Keywords: Micronutrients; antioxidants; vitamin D; selenium; l-carnitine; vitamin C; cancer; treatment related side effects; chemotherapy; radiotherapy Micronutrients; antioxidants; vitamin D; selenium; l-carnitine; vitamin C; cancer; treatment related side effects; chemotherapy; radiotherapy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Gröber, U.; Holzhauer, P.; Kisters, K.; Holick, M.F.; Adamietz, I.A. Micronutrients in Oncological Intervention. Nutrients 2016, 8, 163.

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