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Nutrients 2016, 8(3), 146; doi:10.3390/nu8030146

Heat-Killed Enterococcus faecalis EF-2001 Ameliorates Atopic Dermatitis in a Murine Model

1
Division of Sport Science, College of Science and Technology, Konkuk University, Chungju 380-701, Korea
2
Research & Development Center, Korea BeRM Co. Ltd., Seoul 135-878, Korea
3
Division of Food BioScience, College of Biomedical and Health Sciences, Konkuk University, Chungju 380-701, Korea
4
Department of Food Science & Culinary, International University of Korea, Jinju 660-759, Korea
5
Department of Physical Education, Department of Physical Education, Kunsan National University, Kunsan 54150, Korea
6
Department Pathology, Sanbon Medical Center, Wonkwang University, Sanbon 435-040, Korea
7
Department of Ginseng and Medicinal Herb National Institute of Horticulture Herbal Science, RDA, Chungbuk 27709, Korea
*
Author to whom correspondence should be addressed.
Received: 27 November 2015 / Revised: 24 February 2016 / Accepted: 24 February 2016 / Published: 5 March 2016
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Abstract

Recent reports have shown the immunomodulatory effect of heat-killed lactic acid bacteria. Atopic dermatitis (AD) is an allergic skin disease, caused by immune dysregulation among other factors. The aim of this study was to assess the effect of heat-killed Enterococcus faecalis EF-2001 (EF-2001) on AD. We established an in vivo AD model by repeated local exposure of Dermatophagoides farinae extract (DFE; house dust mite extract) and 2,4-dinitrochlorobenzene (DNCB) to the ears of mice. After oral administration of EF-2001 for four weeks, the epidermal and dermal ear thickness, mast cell infiltration, and serum immunoglobulin levels were measured. In addition, the gene expression levels of pathogenic cytokines in the ears, lymph nodes, and splenocytes were assayed. EF-2001 attenuated AD symptoms based on the ear thickness, histopathological analysis, and serum immunoglobulin levels. Moreover, EF-2001 decreased the DFE/DNCB-induced expression of various pathogenic cytokines in the ears, lymph nodes, and splenocytes. These results suggest that EF-2001 has therapeutic potential in the treatment of AD owing to its immunomodulatory effects. View Full-Text
Keywords: atopic dermatitis; lactic acid bacteria; heat-killed Enterococcus faecalis EF-2001; immunomodulatory; pathogenic cytokines atopic dermatitis; lactic acid bacteria; heat-killed Enterococcus faecalis EF-2001; immunomodulatory; pathogenic cytokines
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Choi, E.-J.; Iwasa, M.; Han, K.-I.; Kim, W.-J.; Tang, Y.; Hwang, Y.J.; Chae, J.R.; Han, W.C.; Shin, Y.-S.; Kim, E.-K. Heat-Killed Enterococcus faecalis EF-2001 Ameliorates Atopic Dermatitis in a Murine Model. Nutrients 2016, 8, 146.

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