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Nutrients 2016, 8(2), 92; doi:10.3390/nu8020092

Phlorizin Supplementation Attenuates Obesity, Inflammation, and Hyperglycemia in Diet-Induced Obese Mice Fed a High-Fat Diet

1,†
,
2,3,†
,
4
,
2,3
and
2,3,*
1
Department of Physiology & Obesity-related Disease Research Center, Keimyung University School of Medicine, Daegu 702-701, Korea
2
Center for Food and Nutritional Genomics Research, Kyungpook National University, 1370 Sankyuk Dong Puk-ku, Daegu 702-701, Korea
3
Department of Food Science and Nutrition, Kyungpook National University, 1370 Sankyuk Dong Puk-ku, Daegu 702-701, Korea
4
Department of Food Science and Nutrition, Pukyong National University, Busan 608-737, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 23 December 2015 / Revised: 27 January 2016 / Accepted: 28 January 2016 / Published: 16 February 2016
(This article belongs to the Special Issue Flavonoids, Inflammation and Immune System)
View Full-Text   |   Download PDF [1206 KB, uploaded 16 February 2016]   |  

Abstract

Obesity, along with its related complications, is a serious health problem worldwide. Many studies reported the anti-diabetic effect of phlorizin, while little is known about its anti-obesity effect. We investigated the beneficial effects of phlorizin on obesity and its complications, including diabetes and inflammation in obese animal. Male C57BL/6J mice were divided into three groups and fed their respective experimental diets for 16 weeks: a normal diet (ND, 5% fat, w/w), high-fat diet (HFD, 20% fat, w/w), or HFD supplemented with phlorizin (PH, 0.02%, w/w). The findings revealed that the PH group had significantly decreased visceral and total white adipose tissue (WAT) weights, and adipocyte size compared to the HFD. Plasma and hepatic lipids profiles also improved in the PH group. The decreased levels of hepatic lipids in PH were associated with decreased activities of enzymes involved in hepatic lipogenesis, cholesterol synthesis and esterification. The PH also suppressed plasma pro-inflammatory adipokines levels such as leptin, adipsin, tumor necrosis factor-α, monocyte chemoattractant protein-1, interferon-γ, and interleukin-6, and prevented HFD-induced collagen accumulation in the liver and WAT. Furthermore, the PH supplementation also decreased plasma glucose, insulin, glucagon, and homeostasis model assessment of insulin resistance levels. In conclusion, phlorizin is beneficial for preventing diet-induced obesity, hepatic steatosis, inflammation, and fibrosis, as well as insulin resistance. View Full-Text
Keywords: phlorizin; obesity; inflammation; insulin resistance; high-fat diet phlorizin; obesity; inflammation; insulin resistance; high-fat diet
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Shin, S.-K.; Cho, S.-J.; Jung, U.J.; Ryu, R.; Choi, M.-S. Phlorizin Supplementation Attenuates Obesity, Inflammation, and Hyperglycemia in Diet-Induced Obese Mice Fed a High-Fat Diet. Nutrients 2016, 8, 92.

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