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Nutrients 2016, 8(12), 780; doi:10.3390/nu8120780

Ulcerative Colitis and Crohn’s Disease Are Associated with Decreased Serum Selenium Concentrations and Increased Cardiovascular Risk

1
Digestive Department, Hospital of Jerez de la Frontera, Cádiz E-11403, Spain
2
Department of Nutrition and Food Chemistry, Faculty of Pharmacy, University of Granada, Granada E-18071, Spain
3
Instituto de Investigación Biosanitaria (IBS), University of Granada, Granada E-18012, Spain
4
Hepatology Department, Granada Hospital Complex, Granada E-18012, Spain
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 26 October 2016 / Revised: 9 November 2016 / Accepted: 25 November 2016 / Published: 1 December 2016
(This article belongs to the Special Issue Nutrition and Diet in IBD)
View Full-Text   |   Download PDF [477 KB, uploaded 1 December 2016]   |  

Abstract

The incidence of inflammatory bowel disease (IBD) and associated oxidative stress is increasing. The antioxidant mineral selenium (Se) was measured in serum samples from 106 IBD patients (53 with ulcerative colitis (UC) and 53 with Crohn’s disease (CD)) and from 30 healthy controls. Serum Se concentrations were significantly lower in UC and CD patients than in healthy controls (p < 0.001) and significantly lower in CD patients than in UC patients (p = 0.006). Se concentrations in patients were significantly influenced by sex, body mass index (BMI), the inflammatory biomarker α-1-antitrypsin, surgery, medical treatment, the severity, extent, and form of the disease and the length of time since onset (p < 0.05). Se concentrations in IBD patients were positively and linearly correlated with nutritional (protein, albumin, prealbumin, cholinesterase and total cholesterol) and iron status-related (hemoglobin, Fe and hematocrit) parameters (p < 0.05). A greater impairment of serum Se and cardiovascular status was observed in CD than in UC patients. An adequate nutritional Se status is important in IBD patients to minimize the cardiovascular risk associated with increased inflammation biomarkers, especially in undernourished CD patients, and is also related to an improved nutritional and body iron status. View Full-Text
Keywords: ulcerative colitis; Crohn’s disease; selenium; influencing factors; nutritional and biochemical markers ulcerative colitis; Crohn’s disease; selenium; influencing factors; nutritional and biochemical markers
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Castro Aguilar-Tablada, T.; Navarro-Alarcón, M.; Quesada Granados, J.; Samaniego Sánchez, C.; Rufián-Henares, J.Á.; Nogueras-Lopez, F. Ulcerative Colitis and Crohn’s Disease Are Associated with Decreased Serum Selenium Concentrations and Increased Cardiovascular Risk. Nutrients 2016, 8, 780.

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