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Nutrients 2016, 8(12), 776; doi:10.3390/nu8120776

Impact of Pre-Pregnancy BMI on B Vitamin and Inflammatory Status in Early Pregnancy: An Observational Cohort Study

1
Laboratory of Clinical Biochemistry, Haukeland University Hospital, 5021 Bergen, Norway
2
Bevital AS, 5021 Bergen, Norway
3
Centre for Clinical Research, Haukeland University Hospital, 5021 Bergen, Norway
4
The Norwegian Institute of Public Health, 0403 Oslo, Norway
5
Nic Waals Institute, Lovisenberg Hospital, Oslo 0456, Norway
6
Department of Public Health and Primary Health Care, University of Bergen, 5007 Bergen, Norway
7
Institute of Clinical Medicine, University of Oslo, 0313 Oslo, Norway
8
Department of Clinical Science, University of Bergen, 5007 Bergen, Norway
*
Author to whom correspondence should be addressed.
Received: 8 September 2016 / Revised: 25 November 2016 / Accepted: 28 November 2016 / Published: 30 November 2016
(This article belongs to the Special Issue B-Vitamins and One-Carbon Metabolism)
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Abstract

Maternal nutrition and inflammation have been suggested as mediators in the development of various adverse pregnancy outcomes associated with maternal obesity. We have investigated the relation between pre-pregnancy BMI, B vitamin status, and inflammatory markers in a group of healthy pregnant women. Cobalamin, folate, pyridoxal 5′-phosphate, and riboflavin; and the metabolic markers homocysteine, methylmalonic acid, and 3-hydroxykynurenine/xanthurenic acid ratio (HK/XA); and markers of cellular inflammation, neopterin and kynurenine/tryptophan ratio (KTR) were determined in pregnancy week 18 and related to pre-pregnancy body mass index (BMI), in 2797 women from the Norwegian Mother and Child Cohort Study (MoBa). Pre-pregnancy BMI was inversely related to folate, cobalamin, pyridoxal 5′-phosphate (PLP), and riboflavin (p < 0.001), and associated with increased neopterin and KTR levels (p < 0.001). Inflammation seemed to be an independent predictor of low vitamin B6 status, as verified by low PLP and high HK/XA ratio. A high pre-pregnancy BMI is a risk factor for low B vitamin status and increased cellular inflammation. As an optimal micronutrient status is vital for normal fetal development, the observed lower B vitamin levels may contribute to adverse pregnancy outcomes associated with maternal obesity and B vitamin status should be assessed in women with high BMI before they get pregnant. View Full-Text
Keywords: pregnancy; obesity; pre-pregnancy BMI; B vitamins; inflammation pregnancy; obesity; pre-pregnancy BMI; B vitamins; inflammation
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Bjørke-Monsen, A.-L.; Ulvik, A.; Nilsen, R.M.; Midttun, Ø.; Roth, C.; Magnus, P.; Stoltenberg, C.; Vollset, S.E.; Reichborn-Kjennerud, T.; Ueland, P.M. Impact of Pre-Pregnancy BMI on B Vitamin and Inflammatory Status in Early Pregnancy: An Observational Cohort Study. Nutrients 2016, 8, 776.

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