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Nutrients 2016, 8(11), 749; doi:10.3390/nu8110749

A Prospective Study of Serum Trace Elements in Healthy Korean Pregnant Women

1
Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-Gu, Seoul 06351, Korea
2
Statistics and Data Center, Research Institute for Future Medicine, Samsung Medical Center, 81 Irwon-Ro, Gangnam-Gu, Seoul 06351, Korea
3
Statistics and Dater Center, Samsung Biomedical Research Institute, 81 Irwon-Ro, Gangnam-Gu, Seoul 06351, Korea
4
Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-Gu, Seoul 06351, Korea
5
Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-Gu, Seoul 06351, Korea
6
Department of Clinical Pharmacology & Therapeutics, Samsung Medical Center, 81 Irwon-Ro, Gangnam-Gu, Seoul 06351, Korea
Current Address: Division of Endocrinology and Metabolism, Department of Medicine, Gyeongsang National University School of Medicine, Jinju 52727, Korea
Current Address: Institute of Health Sciences, Jinju 52727, Korea
§
Current Address: Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul 04401, Korea
*
Authors to whom correspondence should be addressed.
Received: 31 October 2016 / Revised: 16 November 2016 / Accepted: 17 November 2016 / Published: 23 November 2016
View Full-Text   |   Download PDF [667 KB, uploaded 23 November 2016]   |  

Abstract

This prospective study sought to investigate serum levels of trace elements (cobalt, copper, zinc, and selenium) and to assess their effects on pregnancy and neonatal outcomes. Serum levels of trace elements in 245 Korean pregnant women (median gestational age at delivery was 39 + 4 weeks and interquartile range was 38 + 4–40 + 1 weeks) were compared with those of 527 general adults and those of previous studies in other ethnic groups. Pregnancy and neonatal outcomes including gestational diabetes, preeclampsia, neonatal birth weight, and congenital abnormalities were assessed. The median serum trace element concentrations of all pregnant women were: cobalt: 0.39 μg/L (interquartile range, IQR 0.29–0.53), copper: 165.0 μg/dL (IQR 144.0–187.0), zinc: 57.0 μg/dL (IQR 50.0–64.0), and selenium: 94.0 μg/L (IQR 87.0–101.0). Serum cobalt and copper concentrations were higher in pregnant women than in the general population, whereas zinc and selenium levels were lower (p < 0.01). Concentrations of all four trace elements varied significantly during the three trimesters (p < 0.05), and seasonal variation was found in copper, zinc, and selenium, but was not observed for cobalt. The prevalence of preeclampsia was significantly lower with high copper (p = 0.03). Trace element levels varied by pregnancy trimester and season, and alteration in copper status during pregnancy might influence pregnancy outcomes such as preeclampsia. View Full-Text
Keywords: trace elements; zinc; copper; cobalt; selenium; pregnancy trace elements; zinc; copper; cobalt; selenium; pregnancy
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MDPI and ACS Style

Choi, R.; Sun, J.; Yoo, H.; Kim, S.; Cho, Y.Y.; Kim, H.J.; Kim, S.W.; Chung, J.H.; Oh, S.-Y.; Lee, S.-Y. A Prospective Study of Serum Trace Elements in Healthy Korean Pregnant Women. Nutrients 2016, 8, 749.

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