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Nutrients 2016, 8(11), 698; doi:10.3390/nu8110698

Chemopreventive Agents and Inhibitors of Cancer Hallmarks: May Citrus Offer New Perspectives?

1
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina I-98168, Italy
2
Department of Health Sciences, University “Magna Graecia” of Catanzaro, Catanzaro I-88100, Italy
3
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina I-98125, Italy
4
Department of Clinical and Experimental Medicine, University of Messina, Messina I-98125, Italy
5
Institute of Applied Sciences and Intelligent Systems (ISASI), National Research Council (CNR), Pozzuoli I-80078, Italy
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 5 August 2016 / Revised: 11 October 2016 / Accepted: 13 October 2016 / Published: 4 November 2016
(This article belongs to the Special Issue Polyphenols for Cancer Treatment or Prevention)
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Abstract

Fruits and vegetables have long been recognized as potentially important in the prevention of cancer risk. Thus, scientific interest in nutrition and cancer has grown over time, as shown by increasing number of experimental studies about the relationship between diet and cancer development. This review attempts to provide an insight into the anti-cancer effects of Citrus fruits, with a focus on their bioactive compounds, elucidating the main cellular and molecular mechanisms through which they may protect against cancer. Scientific literature was selected for this review with the aim of collecting the relevant experimental evidence for the anti-cancer effects of Citrus fruits and their flavonoids. The findings discussed in this review strongly support their potential as anti-cancer agents, and may represent a scientific basis to develop nutraceuticals, food supplements, or complementary and alternative drugs in a context of a multi-target pharmacological strategy in the oncology. View Full-Text
Keywords: Citrus; cancer; flavonoids; nutraceuticals; functional foods; natural product; complementary and alternative medicines Citrus; cancer; flavonoids; nutraceuticals; functional foods; natural product; complementary and alternative medicines
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Cirmi, S.; Ferlazzo, N.; Lombardo, G.E.; Maugeri, A.; Calapai, G.; Gangemi, S.; Navarra, M. Chemopreventive Agents and Inhibitors of Cancer Hallmarks: May Citrus Offer New Perspectives? Nutrients 2016, 8, 698.

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