The Role of Bioactive Dietary Components in Modulating miRNA Expression in Colorectal Cancer
Abstract
:1. Introduction
2. Biogenesis of miRNA
3. Colorectal Cancer and miRNA
4. Dietary Patterns and miRNA
5. Bioactive Dietary Components and miRNA
5.1. Curcumin
5.2. Resveratrol
5.3. Quercetin
5.4. α-Mangostin
5.5. ω-3-Polyunsaturated Fatty Acids
5.6. Vitamin D
5.7. Dietary Fiber
5.8. Other Dietary Factors
6. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Dietary Component | miRNA Modulated by Dietary Compounds | Molecular Target | Biological Effect | References |
---|---|---|---|---|
Curcumin Curcumin (synthetic analog (CDF)) | ↓miR-21 | PDCD4 | Cell cycle arrest, invasion, metastasis | [72] |
↑miR-34a, ↑miR-34c | Notch-1 | Apoptosis, cell proliferation | [74] | |
↓miR-27a | Sp1, Sp3, Sp4, ZBTB10 | Cell growth, angiogenesis, inflammation | [75] | |
Resveratrol | ↑miR-663, ↓miR-17, ↓miR-21, ↓miR-25, ↓miR-92a-2, ↓miR-103-1, ↓miR-103-2 | TGF-β1, PDCD4, PTEN, Dicer | Cell proliferation | [83] |
↑miR-34a | E2F3 | Growth inhibition | [86] | |
↑miR-96 | KRAS | Chemoprevention, tumor growth | [85] | |
Quercetin Quercetin + Resveratrol | ↑miR-146a | NF-kβ | Inflammation | [96] |
↓miR-27a | Sp1, Sp3, Sp4, ZBTB10 | Cell growth, angiogenesis, inflammation | [97] | |
α-mangostin | ↑miR-143 | ERK-5 | Apoptosis | [102] |
↓miR-133b | DR5 | Apoptosis | [103] | |
ω-3 PUFA | * miR-15b | Bacel, Serbp1 | Plasminogen Activation | [105] |
* miR-107 | Bcl-2, CCNE1 | Apoptosis, Cell cycle | ||
* miR-191, * miR324-5p, * let-7d | - | - | ||
ω-3 PUFA + soluble fiber (pectin) | ↑miR-19b, ↑miR-26b, ↑miR-203 | IGF1R, IGF2R, TCF4 | Cell proliferation, migration | [113] |
Vitamin D | ↑miR-627 | JMJD1A | Cell proliferation | [119] |
↑miR-22 | NELL2, OGN, HNRPH1, RERE, NFAT5 | Cell proliferation, migration | [118] | |
Fiber (butyrate) | ↓miR-17-92 | PTEN, Bcl-2L11, CDKN11A | Cell proliferation, apoptosis | [122,123] |
↓miR-106b | p21 | Cell cycle arrest | [125] |
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Gavrilas, L.I.; Ionescu, C.; Tudoran, O.; Lisencu, C.; Balacescu, O.; Miere, D. The Role of Bioactive Dietary Components in Modulating miRNA Expression in Colorectal Cancer. Nutrients 2016, 8, 590. https://doi.org/10.3390/nu8100590
Gavrilas LI, Ionescu C, Tudoran O, Lisencu C, Balacescu O, Miere D. The Role of Bioactive Dietary Components in Modulating miRNA Expression in Colorectal Cancer. Nutrients. 2016; 8(10):590. https://doi.org/10.3390/nu8100590
Chicago/Turabian StyleGavrilas, Laura I., Corina Ionescu, Oana Tudoran, Cosmin Lisencu, Ovidiu Balacescu, and Doina Miere. 2016. "The Role of Bioactive Dietary Components in Modulating miRNA Expression in Colorectal Cancer" Nutrients 8, no. 10: 590. https://doi.org/10.3390/nu8100590