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Nutrients 2016, 8(10), 597; doi:10.3390/nu8100597

Providing Flaxseed Oil but Not Menhaden Oil Protects against OVX Induced Bone Loss in the Mandible of Sprague-Dawley Rats

Faculty of Applied Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada
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Received: 10 June 2016 / Revised: 1 September 2016 / Accepted: 18 September 2016 / Published: 24 September 2016
(This article belongs to the Special Issue Nutrition and Oral Health)
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Abstract

Higher intakes of polyunsaturated fatty acids (PUFA) are associated with benefits at several skeletal sites in postmenopausal women and in rodent models, but the effect of PUFA-containing oils on tooth-supporting alveolar bone of the mandible has not been studied. Moreover, direct comparison of the effect of flaxseed oil (a source of alpha-linolenic acid (ALA)) and menhaden oil (a source of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) is unknown. One-month old female Sprague-Dawley rats (n = 48) were randomized to and fed a diet containing flaxseed oil or menhaden oil from one to six months of age. At three months of age, rats were randomized to receive SHAM or ovariectomy (OVX) surgery (n = 12/diet). The inter-radicular septum below the first molar of the mandible was imaged at 6 months of age (study endpoint) using micro-computed tomography (μCT) at a resolution of 9 μm. As expected, OVX significantly reduced percent bone volume (BV/TV), connectivity density (Conn. D.), trabecular number (Tb. N.), and increased trabecular separation (Tb. Sp.) compared to SHAM rats (p < 0.001). However, post hoc analysis revealed these differences were present in rats fed menhaden oil but not those fed flaxseed oil. These results suggest that providing flaxseed oil, possibly through its high ALA content, provides protection against the OVX-induced alveolar bone loss in rats. View Full-Text
Keywords: alveolar bone; mandible; micro-computed tomography; omega-3 fatty aids; alpha-linolenic acid; eicosapentaenoic acid; docosahexaenoic acid; ovariectomy; flaxseed oil; fish oil alveolar bone; mandible; micro-computed tomography; omega-3 fatty aids; alpha-linolenic acid; eicosapentaenoic acid; docosahexaenoic acid; ovariectomy; flaxseed oil; fish oil
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MDPI and ACS Style

Longo, A.B.; Ward, W.E. Providing Flaxseed Oil but Not Menhaden Oil Protects against OVX Induced Bone Loss in the Mandible of Sprague-Dawley Rats. Nutrients 2016, 8, 597.

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