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Nutrients 2016, 8(1), 39; doi:10.3390/nu8010039

Effect of Oat β-Glucan Intake on Glycaemic Control and Insulin Sensitivity of Diabetic Patients: A Meta-Analysis of Randomized Controlled Trials

1
School of Public Health, Zunyi Medical University, Zunyi 563000, Guizhou, China
2
College of Food Science, Southwest University, Chongqing 400716, China
3
Chongqing Engineering Research Centre of Regional Foods, Chongqing 400716, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 17 October 2015 / Revised: 9 December 2015 / Accepted: 7 January 2016 / Published: 13 January 2016
(This article belongs to the Special Issue Cereal Grains for Human Health)
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Abstract

Many individual studies on oat β-glucan (OBG) confirmed its functionality in improving type 2 diabetes mellitus (T2DM), but disagreements were identified among those results. To derive a pooled estimate of these results, relevant articles, published before 5 September 2015, were collected from four electronic databases (Pubmed, Cochrane Library, Scopus, and Web of Science) and subjected to meta-analysis in the present work. In total, four articles, dealing with 350 T2DM patients combined, met the inclusion criteria. Compared to control, T2DM patients administrated OBG from 2.5 to 3.5 g/day for 3 to 8 weeks presented significantly lowered concentrations in fasting plasma glucose (FPG) by −0.52 (95% CI: −0.94, −0.10) mmol/L (p = 0.01) and glycosylated hemoglobin (HbA1c) by −0.21% (95% CI: −0.40, −0.02) (p = 0.03). However, OBG intake did not significantly lower the fasting plasma insulin (FPI) concentration. In conclusion, mediate-term OBG intake (3–8 weeks) favored the glycaemic control of T2DM patients but did not improve their insulin sensitivity. Regrettably, data upon the effects of long-term OBG intake on glycaemic control and insulin sensitivity were scarce, which is of much importance and should be addressed in future research. View Full-Text
Keywords: oat β-glucan; diabetes mellitus; glycaemic control; insulin sensitivity; meta-analysis oat β-glucan; diabetes mellitus; glycaemic control; insulin sensitivity; meta-analysis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Shen, X.L.; Zhao, T.; Zhou, Y.; Shi, X.; Zou, Y.; Zhao, G. Effect of Oat β-Glucan Intake on Glycaemic Control and Insulin Sensitivity of Diabetic Patients: A Meta-Analysis of Randomized Controlled Trials. Nutrients 2016, 8, 39.

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