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Nutrients 2015, 7(9), 8127-8151; doi:10.3390/nu7095383

Regulation of Dendritic Cell Function by Vitamin D

1,2,3,†
,
1,3,4,†
and
1,3,*
1
Richard King Mellon Foundation Institute for Pediatric Research, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA
2
Division of Gastroenterology, Hepatology and Nutrition, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA
3
Department of Pediatrics, School of Medicine, University of Pittsburgh Pittsburgh, PA 15224, USA
4
Division of Newborn Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15224, USA
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 29 July 2015 / Revised: 4 September 2015 / Accepted: 10 September 2015 / Published: 21 September 2015
(This article belongs to the Special Issue Immune Regulation by Vitamin D)
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Abstract

Studies over the last two decades have revealed profound immunomodulatory aspects of vitamin D on various aspects of the immune system. This review will provide an overview of Vitamin D metabolism, a description of dendritic cell subsets, and highlight recent advances on the effects of vitamin D on dendritic cell function, maturation, cytokine production and antigen presentation. The active form of vitamin D, 1,25(OH)2D3, has important immunoregulatory and anti-inflammatory effects. Specifically, the 1,25(OH)2D3-Vitamin D3 complex can affect the maturation and migration of many dendritic cell subsets, conferring a special immunoregulatory role as well as tolerogenic properties affecting cytokine and chemokine production. Furthermore, there have been many recent studies demonstrating the effects of Vitamin D on allergic disease and autoimmunity. A clear understanding of the effects of the various forms of Vitamin D will provide new opportunities to improve human health. View Full-Text
Keywords: vitamin D; vitamin D receptor; dendritic cells; innate and adaptive immunity; interleukins; cytokines; inflammation vitamin D; vitamin D receptor; dendritic cells; innate and adaptive immunity; interleukins; cytokines; inflammation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Barragan, M.; Good, M.; Kolls, J.K. Regulation of Dendritic Cell Function by Vitamin D. Nutrients 2015, 7, 8127-8151.

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