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Nutrients 2015, 7(7), 5969-5981; doi:10.3390/nu7075263

Serum Concentrations of Trace Elements in Patients with Tuberculosis and Its Association with Treatment Outcome

5
Medical Microbiology, Innlandet Hospital Trust, Lillehammer N-2629, Norway
1
Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-Gu, Seoul 135-710, Korea
2
Biostatistics and Clinical Epidemiology Center, Samsung Medical Center, 81 Irwon-Ro, Gangnam-Gu, Seoul 135-710, Korea
3
Biostatistics team, Samsung Biomedical Research Institute, 81 Irwon-Ro, Gangnam-Gu, Seoul 135-710, Korea
4
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-Gu, Seoul 135-710, Korea
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 1 July 2015 / Revised: 1 July 2015 / Accepted: 9 July 2015 / Published: 21 July 2015
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Abstract

Deficiencies in essential trace elements are associated with impaired immunity in tuberculosis infection. However, the trace element concentrations in the serum of Korean patients with tuberculosis have not yet been investigated. This study aimed to compare the serum trace element concentrations of Korean adult patients with tuberculosis with noninfected controls and to assess the impact of serum trace element concentration on clinical outcome after antituberculosis treatment. The serum concentrations of four trace elements in 141 consecutively recruited patients with tuberculosis and 79 controls were analyzed by inductively coupled plasma-mass spectrometry. Demographic characteristics were also analyzed. Serum cobalt and copper concentrations were significantly higher in patients with tuberculosis compared with controls, while zinc and selenium concentrations were significantly lower (p < 0.01). Moreover, serum selenium and zinc concentrations were positively correlated (ρ = 0.41, p < 0.05). A high serum copper concentration was associated with a worse clinical outcome, as assessed after one month of antituberculosis therapy. Specifically, culture-positive patients had higher serum copper concentrations than culture-negative patients (p < 0.05). Patients with tuberculosis had altered serum trace element concentrations. Further research is needed to elucidate the roles of individual trace elements and to determine their clinical impact on patients with tuberculosis. View Full-Text
Keywords: tuberculosis; trace elements; inductively coupled plasma-mass spectrometry; Korea tuberculosis; trace elements; inductively coupled plasma-mass spectrometry; Korea
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Choi, R.; Kim, H.-T.; Lim, Y.; Kim, M.-J.; Kwon, O.J.; Jeon, K.; Park, H.Y.; Jeong, B.-H.; Koh, W.-J.; Lee, S.-Y. Serum Concentrations of Trace Elements in Patients with Tuberculosis and Its Association with Treatment Outcome. Nutrients 2015, 7, 5969-5981.

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