Impact of Weight Loss on Plasma Leptin and Adiponectin in Overweight-to-Obese Post Menopausal Breast Cancer Survivors
Abstract
:1. Introduction
2. Experimental Section
2.1. Study Design
2.2. Participants
2.3. Adverse Events
2.4. Non Intervention Control
2.5. Intervention
2.6. Laboratory Analyses
2.7. Statistical Methods
3. Results
3.1. Anthropometric Determinates
Variable | Group | Baseline | Month 1 | Month 2 | Month 3 | Month 4 | Month 5 | Month 6 |
---|---|---|---|---|---|---|---|---|
Body Weight (kg) | CTRL | 53, 79.7 ± 9.3 (11.7) | 53, 79.4 ± 10.1 (12.7) | |||||
LC | 65, 79.8 ± 8.7 (10.9) | 65, 76.0 ± 8.4 (11.1) | 65, 74.0 ± 8.4 (11.4) | 64, 72.3 ± 8.4 (11.7) | 62, 71.2 ± 8.7 (12.2) | 61, 70.2 ± 8.9 (12.6) | 65, 69.4 ± 9.0 (13.0) | |
LF | 73, 77.6 ± 7.7 (9.9) | 73, 74.2 ± 7.4 (10.0) | 71, 72.3 ± 7.5 (10.3) | 69, 71.1 ± 7.5 (10.5) | 69, 70.0 ± 7.4 (10.6) | 67, 69.0 ± 7.6 (11.0) | 73, 68.3 ± 7.5 (11.0) | |
Fat Mass (kg) | CTRL | 53, 34.9 ± 7.3 (20.9) | 53, 34.9 ± 8.2 (23.4) | |||||
LC | 65, 35.0 ± 6.1 (17.4) | 65, 31.9 ± 5.7 (18.0) | 65, 30.2 ± 5.6 (18.7) | 64, 28.5 ± 5.8 (20.5) | 62, 27.4 ± 6.2 (22.5) | 61, 26.1 ± 6.4 (24.5) | 65, 25.4 ± 6.6 (26.1) | |
LF | 73, 33.0 ± 5.8 (17.6) | 73, 29.8 ± 5.7 (19.2) | 71, 28.1 ± 5.6 (19.8) | 69, 26.7 ± 5.8 (21.6) | 69, 25.7 ± 5.6 (21.8) | 67, 24.8 ± 5.9 (23.9) | 73, 24.1 ± 5.7 (23.7) | |
Waist (cm) | CTRL | 53, 94.9 ± 8.3 (8.7) | 53, 94.8 ± 8.8 (9.3) | |||||
LC | 65, 94.3 ± 6.9 (7.4) | 65, 91.6 ± 7.5 (8.2) | 65, 89.8 ± 7.6 (8.4) | 64, 87.8 ± 7.6 (8.6) | 62, 87.1 ± 7.7 (8.9) | 61, 86.0 ± 7.7 (8.9) | 65, 85.0 ± 7.5 (8.8) | |
LF | 73, 91.6 ± 7.2 (7.9) | 73, 89.0 ± 6.8 (7.6) | 71, 86.7 ± 7.0 (8.1) | 69, 85.6 ± 7.8 (9.1) | 69, 84.4 ± 7.0 (8.3) | 67, 83.5 ± 7.3 (8.7) | 73, 83.1 ± 7.4 (8.9) | |
Hip (cm) | CTRL | 53, 110.5 ± 7.4 (6.7) | 53, 111.0 ± 9.2 (8.3) | |||||
LC | 65, 112.0 ± 7.2 (6.4) | 65, 109.3 ± 6.9 (6.3) | 65, 107.4 ± 6.9 (6.5) | 64, 106.1 ± 7.3 (6.9) | 62, 104.7 ± 7.3 (7.0) | 61, 103.9 ± 8.2 (7.9) | 65, 103.2 ± 7.3 (7.1) | |
LF | 73, 110.7 ± 5.8 (5.2) | 73, 107.6 ± 5.8 (5.3) | 71, 105.9 ± 6.2 (5.8) | 69, 105.1 ± 5.4 (5.1) | 69, 103.7 ± 5.3 (5.1) | 67, 102.8 ± 6.1 (6.0) | 73, 102.2 ± 5.6 (5.5) | |
WHR | CTRL | 53, 0.9 ± 0.1 (8.2) | 53, 0.9 ± 0.1 (9.1) | |||||
LC | 65, 0.8 ± 0.1 (7.9) | 65, 0.8 ± 0.1 (7.9) | 65, 0.8 ± 0.1 (9.0) | 64, 0.8 ± 0.1 (8.1) | 62, 0.8 ± 0.1 (7.6) | 61, 0.8 ± 0.1 (8.5) | 65, 0.8 ± 0.1 (7.5) | |
LF | 73, 0.8 ± 0.1 (6.7) | 73, 0.8 ± 0.1 (6.4) | 71, 0.8 ± 0.1 (6.7) | 69, 0.8 ± 0.1 (7.5) | 69, 0.8 ± 0.1 (6.7) | 67, 0.8 ± 0.1 (6.7) | 73, 0.8 ± 0.1 (6.8) |
3.2. Fat Mass and Plasma Concentrations of Leptin and Adiponectin
3.3. Pattern of Change
Variable | Group | Baseline | Month 1 | Month 2 | Month 3 | Month 4 | Month 5 | Month 6 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Adiponectin (μg/mL) | CTRL | 53, 12.1 ± 7.2 (59.8) | 52, 12.5 ± 6.8 (54.0) | |||||||||||||
LC | 65, 11.9 ± 7.3 (61.3) | 65, 11.4 ± 6.8 (59.6) | 65, 11.6 ± 6.1 (52.6) | 63, 12.1 ± 6.3 (52.3) | 62, 12.3 ± 6.2 (50.7) | 61, 13.0 ± 6.4 (49.4) | 65, 12.7 ± 6.7 (52.9) | |||||||||
LF | 72, 14.0 ± 5.7 (41.0) | 73, 12.5 ± 5.4 (43.1) | 71, 12.8 ± 5.4 (42.4) | 69, 13.6 ± 5.6 (40.8) | 69, 13.7 ± 5.4 (39.2) | 66, 13.9 ± 5.9 (42.2) | 72, 15.0 ± 6.3 (42.1) | |||||||||
Adiponectin (%) ∆ from baseline | CTRL | 52, 10.6 ± 38.7 (363) | ||||||||||||||
LC | 65, −3.4 ± 20.7 (−615) | 65, 2.5 ± 23.2 (925) | 63, 6.8 ± 25.7 (381) | 62, 10.5 ± 32.3 (309) | 61, 14.1 ± 32.7 (231) | 65, 13.0 ± 25.7 (198) | ||||||||||
LF | 72, −7.8 ± 21.8(−279) | 71, −6.0 ± 25.1 (−420) | 69, 1.1 ± 23.3 (2093) | 69, 2.9 ± 27.7 (961) | 66, 2.7 ± 24.5 (918) | 71, 12.1 ± 27.0 (223) | ||||||||||
Leptin (ng/mL) | CTRL | 53, 34.6 ± 17.7 (51.2) | 52, 35.1 ± 19.4 (55.3) | |||||||||||||
LC | 65, 36.5 ± 16.2 (44.5) | 65, 20.0 ± 9.7 (48.5) | 65, 18.4 ± 10.5 (57.2) | 63, 17.3 ± 10.4 (60.0) | 62, 16.5 ± 10.6 (64.4) | 61, 16.4 ± 11.1 (68.0) | 65, 16.4 ± 11.8 (71.8) | |||||||||
LF | 72, 35.1 ± 20.7 (59.1) | 73, 18.9 ± 11.2 (59.0) | 71, 17.7 ± 11.7 (66.4) | 69, 17.6 ± 11.3 (63.9) | 69, 15.8 ± 9.0 (57.2) | 66, 15.0 ± 10.5 (69.7) | 72, 15.3 ± 9.8 (64.0) | |||||||||
Leptin (%) ∆ from baseline | CTRL | 52, 6.5 ± 41.7 (643) | ||||||||||||||
LC | 65, −43 ± 20.1 (−47) | 65, −46 ± 25.9 (−56) | 63, −50 ± 23.5 (−47) | 62, −53 ± 24.5 (−46) | 61, −53 ± 26.2 (−49) | 65, −52 ± 30.6 (−59) | ||||||||||
LF | 72, −44 ± 17.6 (−40) | 71, −48 ± 20.5 (−42) | 69, −48 ± 24.0 (−50) | 69, −53 ± 18.6 (−35) | 66, −54 ± 24.2 (−45) | 71, −51 ± 31.9 (−62) | ||||||||||
Ratio Adiponectin/eptin | CTRL | 53, 0.5 ± 0.4 (87.0) | 52, 0.5 ± 0.4 (78.0) | |||||||||||||
LC | 65, 0.4 ± 0.5 (119) | 65, 0.8 ± 1.0 (123) | 65, 0.9 ± 1.0 (112) | 63, 1.1 ± 1.3 (121) | 62, 1.2 ± 1.3 (114) | 61, 1.4 ± 2.5 (175) | 65, 1.4 ± 2.1 (144) | |||||||||
LF | 72, 0.6 ± 0.4 (75.1) | 73, 0.9 ± 0.6 (68.5) | 71, 1.1 ± 0.9 (83.5) | 69, 1.2 ± 1.0 (87.0) | 69, 1.3 ± 1.1 (85.4) | 66, 1.4 ± 1.4 (96.7) | 72, 1.6 ± 1.7 (108) |
3.4. Impact of Weight Loss Magnitude
3.5. Clinical Relevance of Changes in Plasma Adipokines
4. Discussion
4.1. Leptin
4.2. Adiponectin
4.3. Adiponectin to Leptin Ratio and Causal Mechanisms
4.4. Strengths and Limitations
5. Conclusions
Supplementary Files
Supplementary File 1Acknowledgments
Author Contributions
Conflicts of Interest
References
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Thompson, H.J.; Sedlacek, S.M.; Wolfe, P.; Paul, D.; Lakoski, S.G.; Playdon, M.C.; McGinley, J.N.; Matthews, S.B. Impact of Weight Loss on Plasma Leptin and Adiponectin in Overweight-to-Obese Post Menopausal Breast Cancer Survivors. Nutrients 2015, 7, 5156-5176. https://doi.org/10.3390/nu7075156
Thompson HJ, Sedlacek SM, Wolfe P, Paul D, Lakoski SG, Playdon MC, McGinley JN, Matthews SB. Impact of Weight Loss on Plasma Leptin and Adiponectin in Overweight-to-Obese Post Menopausal Breast Cancer Survivors. Nutrients. 2015; 7(7):5156-5176. https://doi.org/10.3390/nu7075156
Chicago/Turabian StyleThompson, Henry J., Scot M. Sedlacek, Pamela Wolfe, Devchand Paul, Susan G. Lakoski, Mary C. Playdon, John N. McGinley, and Shawna B. Matthews. 2015. "Impact of Weight Loss on Plasma Leptin and Adiponectin in Overweight-to-Obese Post Menopausal Breast Cancer Survivors" Nutrients 7, no. 7: 5156-5176. https://doi.org/10.3390/nu7075156