Next Article in Journal
Hypolipidemic Effects and Safety of Lactobacillus Reuteri 263 in a Hamster Model of Hyperlipidemia
Next Article in Special Issue
Dietary Fiber Intake is Associated with Increased Colonic Mucosal GPR43+ Polymorphonuclear Infiltration in Active Crohn’s Disease
Previous Article in Journal
Carbohydrate Electrolyte Solutions Enhance Endurance Capacity in Active Females
Previous Article in Special Issue
Hepatoprotective Effect of Herb Formula KIOM2012H against Nonalcoholic Fatty Liver Disease
Article Menu

Export Article

Open AccessArticle
Nutrients 2015, 7(5), 3751-3766; doi:10.3390/nu7053751

Impact of Leucine Supplementation on Exercise Training Induced Anti-Cardiac Remodeling Effect in Heart Failure Mice

Biosciences Department, Federal University of São Paulo, Santos, 11015-020, Brazil
School of Physical Education and Sport, University of São Paulo, São Paulo, 05508-900, Brazil
Post-graduation Program in Medicine, Nove de Julho University (UNINOVE), São Paulo, 01504-001, Brazil
Author to whom correspondence should be addressed.
Received: 5 February 2015 / Revised: 13 April 2015 / Accepted: 5 May 2015 / Published: 15 May 2015
(This article belongs to the Special Issue Nutrition in Medicine)
View Full-Text   |   Download PDF [462 KB, uploaded 15 May 2015]   |  


Leucine supplementation potentiates the effects of aerobic exercise training (AET) on skeletal muscle; however, its potential effects associated with AET on cardiac muscle have not been clarified yet. We tested whether leucine supplementation would potentiate the anti-cardiac remodeling effect of AET in a genetic model of sympathetic hyperactivity-induced heart failure in mice (α2A2CARKO). Mice were assigned to five groups: wild type mice treated with placebo and sedentary (WT, n = 11), α2A2CARKO treated with placebo and sedentary (KO, n = 9), α2A2CARKO treated with leucine and sedentary (KOL, n = 11), α2A2CARKO treated with placebo and AET (KOT, n = 12) or α2A2CARKO treated with leucine and AET (KOLT, n = 12). AET consisted of four weeks on a treadmill with 60 min sessions (six days/week, 60% of maximal speed) and administration by gavage of leucine (1.35 g/kg/day) or placebo (distilled water). The AET significantly improved exercise capacity, fractional shortening and re-established cardiomyocytes’ diameter and collagen fraction in KOT. Additionally, AET significantly prevented the proteasome hyperactivity, increased misfolded proteins and HSP27 expression. Isolated leucine supplementation displayed no effect on cardiac function and structure (KOL), however, when associated with AET (KOLT), it increased exercise tolerance to a higher degree than isolated AET (KOT) despite no additional effects on AET induced anti-cardiac remodeling. Our results provide evidence for the modest impact of leucine supplementation on cardiac structure and function in exercised heart failure mice. Leucine supplementation potentiated AET effects on exercise tolerance, which might be related to its recognized impact on skeletal muscle. View Full-Text
Keywords: heart failure; aerobic exercise training; leucine; cardiac remodeling heart failure; aerobic exercise training; leucine; cardiac remodeling

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

de Moraes, W.M.A.M.; Melara, T.P.; de Souza, P.R.M.; de Salvi Guimarães, F.; Bozi, L.H.M.; Brum, P.C.; Medeiros, A. Impact of Leucine Supplementation on Exercise Training Induced Anti-Cardiac Remodeling Effect in Heart Failure Mice. Nutrients 2015, 7, 3751-3766.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top